Publication

[Developmental Biology] Researchers reported a protocol for small molecule-mediated induction of the neural crest state from blastula stem cells and validated it using transcriptome analysis and grafting experiments.

[Journal Of Reproduction And Development] Investigators derived iPS cells from cat embryonic fibroblasts retrovirally transfected with mouse Oct3/4, Klf4, Sox2, and c-Myc. After transfection, embryonic fibroblasts were reseeded onto inactivated SNL 76/7 and cultured in a medium supplemented with basic fibroblast growth factor.

[International Immunopharmacology] The authors elucidated the intrinsic mechanisms underlying the therapeutic effects of human UC-MSCs in liver fibrosis patients.

[Development] Using trophoblast stem cells, trophoblast organoids and primary cytotrophoblasts of early pregnancy, researchers showed that autocrine NOTCH3 signaling controlled human placental expansion and differentiation.

[Current Stem Cell Research & Therapy] Researchers evaluated the efficacy and safety of allogeneic umbilical cord-derived MSCs for complex perianal fistula in patients with Crohn’s disease.

[Journal Of Nanobiotechnology] Scientists demonstrated that human UCMSCs-Exos-encapsulated poly lactic-co-glycolic acid nanoparticles stimulated osteogenic differentiation while inhibiting the generation of reactive oxygen species and subsequent osteoclast differentiation in vitro.