Publication

[Nature Communications] The authors discovered that isocitrate dehydrogenase type 1 (IDH1) mutation inhibited virus-induced interferon antiviral responses in glioma cells.

[Science Advances] Investigators examined the effect of human cerebrospinal fluid (CSF) on glioblastoma (GBM) tumors from 25 patients. They found that CSF induces tumor cell plasticity and resistance to standard GBM treatments, temozolomide and irradiation.

[Cell Death Discovery] Zinc finger protein 281 (ZNF281) knockdown increased the expression of mitochondrial transcription factor A in HCC cells, accompanied with increment of mitochondrial content, oxygen consumption rate and levels of tricarboxylic acid cycle intermetabolites.

[Biology Direct] The authors explored the role of nuclear respiratory factor 1 in HCC progression and investigated the underlying mechanisms.

[Scientific Reports] Researchers found that the abundance of pancreatic ductal adenocarcinoma (PDAC) stemness negatively influenced the infiltration of NK cells and identified the transcription factor ONECUT3 enriched in PDACs with high stemness index scores and Pan-Cancer Stemness Signature levels.

[Research] Investigators explored the expression, function, and mechanism of AZGP1P2, a pseudogene of AZGP1, in regulating the stemness and apoptosis of PCSCs and treatment resistance of docetaxel in castration-resistant prostate cancer.