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Tuning Porosity of Macroporous Hydrogels Enables Rapid Rates of Stress Relaxation and Promotes Cell Expansion and Migration

[Proceedings of The National Academy of Sciences of The United States of America] Investigators developed macroporous alginate hydrogels that had an order of magnitude increase in the rate of stress relaxation as compared to bulk hydrogels.

Targeting a Chemo-Induced Adaptive Signaling Circuit Confers Therapeutic Vulnerabilities in Pancreatic Cancer

[Cell Discovery] Investigators reported a previously unknown chemo-induced symbiotic signaling circuit that adaptively conferred chemoresistance in patients and mice with advanced PDAC.

Reprogramming Astroglia into Neurons with Hallmarks of Fast-Spiking Parvalbumin-Positive Interneurons by Phospho-Site–Deficient Ascl1

[Science Advances] Scientists investigated the consequences of mutating six serine phospho-acceptor sites to alanine on lineage reprogramming in vivo.

Apoptosis Signaling Is Activated as a Transient Pulse in Neurons

[Cell Death & Differentiation] The authors investigated whether the apoptotic pathway in neurons was a persistent signal or a transient pulse in continuous presence of apoptotic stimulus.

Neuronal Cathepsin S Increases Neuroinflammation and Causes Cognitive Decline via CX3CL1-CX3CR1 Axis and JAK2-STAT3 Pathway in Aging and Alzheimer’s Disease

[Aging Cell] Researchers investigated the role of neuronal cathepsin S (CTSS) in aging and Alzheimer's disease started by examining CTSS expression in hippocampus neurons of aging mice and identified a significant increase, which was negatively correlated with recognition abilities.

Inflammation Impacts Androgen Receptor Signaling in Basal Prostate Stem Cells Through Interleukin 1 Receptor Antagonist

[Communications Biology] Using a unique transgenic mouse model that mimicked chronic non-bacterial prostatitis in men, researchers investigated the impact of inflammation on androgen receptor in basal prostate stem cells and their differentiation in vivo.

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