Publication

[Nature Immunology] The authors profiled >300,000 single T cells from healthy children and older adults by using the trimodal assay TEA-seq, which revealed that molecular programming of T cell subsets shifted toward a more activated basal state with age.

[Cell Reports] Investigators constructed a longitudinal high-precision single-cell transcriptomic landscape of 7,578 CAR-T cells from 26 patients with B cell acute lymphoblastic leukemia post-infusion.

[Advanced Healthcare Materials] Mesoporous silica was used as a model material of Si-based biomaterials. Experiments showed that the supernatant of CD4+ T lymphocytes pretreated with mesoporous silica extract significantly promoted the vascularized bone regeneration.

[EMBO Reports] Researchers described a new role for the autophagy-inducing serine/threonine kinases ULK1 and ULK2 in mechanotransduction, and showed that ULK1/2 activity inhibited the assembly of actin stress fibers and focal adhesions.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] To address the functional coupling of ECM composition and matrix rigidity on compliant substrates, investigators developed a matrix spot array system to screen cell phenotypes against different ECM mixtures on defined substrate stiffnesses at high resolution.

[Biomaterials Science] To understand the role of physicochemical surface effects on the dedifferentiation of patient-derived mature adipocytes, the surfaces of cell culture flasks were coated with extracellular matrix, basement membrane proteins, and cationic/anionic polymers.