Publication

[Human Molecular Genetics] Researchers analyzed the human vascular endothelial cells by utilizing the isogenic pairs of T21-iPSCs and corrected disomy 21-iPSCs.

[Regenerative Therapy] Scientists developed a human PSC-based system that models the human intramembranous ossification process. They found that spheroid culture of the hPSC-derived paraxial mesoderm derivatives generated osteoprogenitors or osteo-chondroprogenitors depending on stimuli.

[Cell Death & Disease] RNA polymerase mitochondria (POLRMT) is essential for mitochondrial transcription machinery and other mitochondrial functions. Researchers explored its expression and potential functions in prostate cancer.

[Cell Death & Disease] Researchers revealed that RNF5 negatively regulated Ephrin receptor A2 (EphA2) properties and suppressed its tumor-suppressive function in HER2-negative breast cancers.

[Cell Stem Cell] Scientists presented quality, safety, and efficacy data supporting the first-in-human STEM-Parkinson’s disease phase I/IIa clinical trial along with the trial design.

[Cell Reports] Researchers identified that ECM stiffness was an important biophysical cue to regulate tumor immunogenicity via the Rho-associated coiled-coil-containing protein kinase-myosin IIA-filamentous actin axis.