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Engineered Bone Marrow as a Clinically Relevant Ex Vivo Model for Primary Bone Cancer Research and Drug Screening

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors adapted a previously described engineered bone marrow construct for use as a three-dimensional platform to study how microenvironmental and immune factors affect osteosarcoma tumor progression.

δ-Tocotrienol Preconditioning Improves the Capability of Bone Marrow-Derived Mesenchymal Stem Cells in Promoting Wound Healing by Inhibiting BACH1-Related Ferroptosis

[Cell Death Discovery] Investigators explored the role of δ-Tocotrienol in bone marrow-derived MSC ability of wound healing. Transcriptome and single-cell analysis were used to explore the genes and pathways related to ferroptosis in wound tissues.

Therapeutic Potential of Oral-Derived Mesenchymal Stem Cells in Retinal Repair

[Stem Cell Reviews And Reports] Researchers comprehensively explored the potential of various types of stem cells from oral cavity as promising therapeutic options in retinal regeneration.

Adipose-Derived Mesenchymal Stem Cells -Conditioned Medium Effects on Glioma U87 Migration, Apoptosis, and Gene Expression

[Tissue and Cell] Using flow cytometry, adipose tissue-derived MSCs were identified, verified, and their conditioned media was used to treat U87 cells. Through RT-qPCR, scratch assay, and apoptosis analysis, scientists evaluated gene expression, cell migration, and apoptosis in U87 cells.

A CCL2+DPP4+ Subset of Mesenchymal Stem Cells Expedites Aberrant Formation of Creeping Fat in Humans

[Nature Communications] Investigators characterized creeping fat as pro-adipogenic and pro-fibrotic. Lipidomics analysis of Crohn’s disease patients and healthy controls revealed abnormal lipid metabolism in creeping fat.

Human Macrophage Migration Inhibitory Factor Potentiates Mesenchymal Stromal Cell Efficacy in a Clinically Relevant Model of Allergic Asthma

[Molecular Therapy] Scientists investigated the efficacy of human MSCs in high vs low human macrophage migration inhibitory factor (hMIF) environments and the impact of MIF pre-licensing of MSCs using humanized MIF mice in a clinically relevant house dust mite model of allergic asthma.

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