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Mesenchymal Cell News
Impact of Elastic Substrate on the Dynamic Heterogeneity of WC256 Walker Carcinosarcoma Cells
[Scientific Reports] The authors demonstrated that cellular heterogeneity could be highly dynamic and dependent on the micromechanical properties of the substrate.
Neural Cell News
Microglia-Dependent Neuroprotective Effects of 4-Octyl Itaconate Against Rotenone– and MPP+–Induced Neurotoxicity in Parkinson’s Disease
[Scientific Reports] Researchers investigated the neuroprotective potential of 4-octyl itaconate, a cell-permeable derivative of itaconate, in cellular models of Parkinson’s disease.
Neural Cell News
Stem Cells-Derived Exosomes Alleviate Neurodegeneration and Alzheimer’s Pathogenesis by Ameliorating Neuroinflamation, and Regulating the Associated Molecular Pathways
[Scientific Reports] Investigators examined how NSC-exos could protect human neuroblastoma cells SH-SY5Y. NSC-exos were derived from human NSCs by ultracentrifugation and the therapeutic effects of the NSC-exos were then investigated in vitro.
Newsletters
Spatiotemporal, Optogenetic Control of Gene Expression in Organoids
[Nature Methods] Scientists combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns.
Immune Regulation News
Lung Tumor–Infiltrating Treg Have Divergent Transcriptional Profiles and Function Linked to Checkpoint Blockade Response
[Science Immunology] Researchers identified 10 subsets of human tumor-infiltrating-Treg, most of which had high concordance with murine tumor-infiltrating-Treg subsets.
Immune Regulation News
Bone Marrow Immune Cells Respond to Fluctuating Nutritional Stress to Constrain Weight Regain
[Cell Metabolism] Scientists identified a stem cell-like CD7+ monocyte subpopulation accumulating in the bone marrow of mice and humans that experienced dieting-induced weight loss.