Publication

[AAPS Pharmscitech] Scientists assessed the potential of liposomal formulations of thymoquinone and Egyptian propolis extract in combination therapy to improve their therapeutic efficacy against ulcerative colitis in order to maximize the potential of their beneficial clinical effects.

[Journal Of Radiation Research] Researchers studied the therapeutic mechanism of Liangxue-Guyuan-Yishen decoction (LGYD) on gastrointestinal acute radiation syndrome (GI-ARS) and to provide a new scheme for the treatment of radiation injury. They investigated the effects of LGYD on intestinal stem cells in a GI-ARS rat model.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Using a candidate drug screen, the authors identified that inhibition of cyclin-dependent kinases 12 and 13 (CDK12/13) dramatically sensitized diverse models of TNBC to epidermal growth factor receptor (EGFR) blockade.

[British Journal of Cancer] Gene knockdown and overexpression were employed to examine the impact of HSP90AA1 on intracellular NME1 degradation. The motility and invasiveness of breast cancer cells were examined in vitro.

[EMBO Reports] Researchers investigated the expression of N6-methyladenosine (m6A) regulatory proteins in breast cancer. They found that expression of KIAA1429/VIRMA was upregulated in breast cancer tissue and correlated positively with poor survival.

[Molecular Oncology] To elaborate the roles of TAZ in TNBC, the authors depleted Taz in murine TNBC 4T1 cells, using either CRISPR/Cas9 or small hairpin RNA. TAZ depletion resulted in smaller tumors compared to the tumors generated by control cells.