Publication

[Scientific Reports] Ten novel thiazoloquinoxaline derivatives coupled with different sulfonamide moieties were designed and synthesized fulfilling pharmacophoric features of vascular endothelial growth factor receptor (VEGFR)-2 inhibition.

[Scientific Reports] Investigators searched for age-associated genes to identify senescent cells in the livers of aged animals. They performed scRNA-seq to screen candidates for age-associated genes using young and aged rat primary hepatocytes.

[Molecular and Cellular Biochemistry] The authors reported that RasGRP1 physically interacted with the adaptor protein Src homolog and collagen homolog 3 (Shc3).

[Functional & Integrative Genomics] Scientists evaluated the potential role of kinesin family (KIF) 11 in HCC. The effect of KIF11 was evaluated using the hepatocellular carcinoma cell lines, LM3 and Huh7, after genetic or pharmacological treatment.

[Molecular Biology Reports] The NIH Gene Expression Omnibus and Oncomine datasets were analyzed for HCC cell lines with relatively low and high toll-interacting protein expression, and SNU449 and Hep3B cell lines were chosen, respectively.

[Journal Of Cell Science] Investigators knocked out each ErbB gene, various combinations of ErbB genes or all ErbB genes in Madin–Darby canine kidney cells to delineate the contribution of each gene.