Publication

[Science Immunology] Scientists compared T cells from the joints of 20 patients with an inflammatory arthritis induced by immune checkpoint inhibitor therapy with two archetypal autoimmune arthritides, rheumatoid arthritis and psoriatic arthritis.

[Nature Communications] Researchers demonstrated that Enhancer of zeste homolog 2 (Ezh2) serves as an epigenetic checkpoint regulator during monocyte to macrophage differentiation.

[EMBO Molecular Medicine] Investigators performed in-depth single-cell sequencing on muscle-infiltrating T cells and peripheral blood memory T cells in six patients with recently diagnosed idiopathic inflammatory myopathies.

[Cancer Research] Researchers identified increased expression of the adhesion molecule immunoglobulin superfamily member 9 (IGSF9) in tumor cells and tumor-infiltrating immune cells across multiple cancer types.

[Nano Letters] Investigators developed a nonviral T cell nanoengineering system that allowed highly efficient delivery of diverse functional nanomaterials into primary human T cells in a genetically stable and scalable manner.

[Cell Reports] The authors showed that the critical role of solute carrier family 15 member 4 (SLC15A4) in endolysosomal toll-like receptor (TLR) 7–9 responses was to mediate lysosomal recruitment of TASL.