Publication

[Scientific Reports] This preclinical study evaluated the metabolic dysfunction-associated steatotic liver disease development in a lean gestational diabetes mellitus mouse model with impaired insulin secretion capacity.

[Journal of Cellular and Molecular Medicine] The authors studied young rats to establish abdominal aorta coarctation (AAC) for four weeks. AAC-induced rats showed enlarged myocardiocytes and alterations in microRNAs, especially downregulated miR-31-5p. miR-31-5p targeted the 3′UTR of Nfatc2ip and inhibited myocardial hypertrophy in vitro and in vivo.

[PLOS Biology] Investigators reported that potassium two pore domain channel subfamily K member 1 (KCNK1) was significantly up-regulated in human breast cancer and was correlated with poor prognosis in breast cancer patients. KCNK1 promoted breast cancer proliferation, invasion, and metastasis in vitro and in vivo.

[Signal Transduction and Targeted Therapy] Scientists developed engineered extracellular vesicles for the targeted reprogramming of cancer-associated fibroblasts and modulating the tumor microenvironment in pancreatic cancer.

[Autophagy] The authors explored the potential protective effects of (-)-epigallocatechin 3-gallate on β-cell-specific NR3C1 overexpression mice in vivo and NR3C1-enhanced β cells in vitro.

[Proceedings of The National Academy of Sciences of The United States of America] CAR T cell infusion resulted in reduced leg stiffness, drastic improvement in gait, walking speed increase over 100%, and daily walking distance improvement from less than 50 m to over 6 km within 3 months.