Review

[Expert Review of Clinical Immunology] Scientists explore the role of Tregs in the immune system, delve into their contribution to cancer and tumor progression, and highlight therapeutic strategies targeting Tregs, along with innovative delivery systems.

[American Journal of Hematology] The authors examine current strategies to enhance CAR-T cell durability, focusing on recent advances in CAR structural design, gene editing techniques, ex vivo culture optimization, clinical management approaches, and in vivo preparation.

[Clinical Reviews in Allergy & Immunology] The authors synthesize the current clinical and experimental evidence linking COVID-19 to autoimmune and inflammatory sequelae.

[Journal of Translational Medicine] Investigators systematically elucidate the molecular mechanisms by which hypoxia-inducible factor and key m6A-modifying enzymes jointly regulate HCC progression within the hypoxic microenvironment.

[Experimental Hematology & Oncology] The authors summarize distinctive features of the tumor–immune microenvironment in small cell lung cancer and evaluate current immunotherapeutic strategies, notably immune checkpoint inhibitors, that have demonstrated survival benefits in a subset of patients.

[Nature Reviews Clinical Oncology] The authors synthesize molecular mechanisms that underlie resistance to third-generation EGFR tyrosine kinase inhibitors and discuss emerging approaches to pre-empt resistance through early application of combination therapies.