Review

[Cell and Tissue Research] Investigators discuss current challenges and future directions for using CRISPR-based screens in furthering our understanding of neurological diseases and developing potential therapeutic strategies.

[Advanced Science] Scientists review the latest sophisticated technologies employed in the design of immunomodulatory hydrogels to regulate macrophage polarization. The design of hydrogels to deliver targeted immune stimulation through manipulation of chemistry and cell integration is also emphasized.

[Small] The authors discuss the composition of the mineralized ECM in bone tissue to provide guidance for biomimetic collagen mineralization.

The authors highlight the potential of targeting the leptin receptor and its cellular signaling in suppressing breast cancer progression. [Naunyn-Schmiedebergs Archives of Pharmacology] Abstract

[Trends In Neurosciences] Is circadian disruption a cause, consequence, or a parallel feature of Parkinson's disease that shares the same root cause? The authors address this question by highlighting and discussing clinical evidence and findings from experiments using vertebrate and invertebrate animal models.

[Medical Oncology] The authors examine telomerase activation in breast cancer and breast cancer stem cells and the therapeutic effects of telomerase inhibition in these cells.They highlight the importance and impact of telomerase inhibition in the treatment of breast cancer and the lack of studies specifically in breast cancer stem cells.