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Potent Molecular-Targeted Therapies for Gastro-Entero-Pancreatic Neuroendocrine Carcinoma

[Cancer And Metastasis Reviews] The authors summarize the biology, current treatments, and molecular profiles of gastro-entero-pancreatic neuroendocrine carcinoma based on the findings of pivotal comprehensive molecular analyses.

Type 2 Immunity in the Brain and Brain Borders

[Cellular & Molecular Immunology] The authors discuss the beneficial and detrimental roles of type 2 immune cells and cytokines in central nervous system injury and homeostasis, cognition, and diseases such as tumors, Alzheimer’s disease and multiple sclerosis.

Germinal Center-Dependent and -Independent Immune Responses of Tumor-Infiltrating B Cells in Human Cancers

[Cellular & Molecular Immunology] Investigators highlight the need for more integrative B cell immunology studies to rationally investigate TIL-B cells as a leverage for antitumor therapies.

Role of B Cells in Immune-Related Adverse Events Following Checkpoint Blockade

[Immunological Reviews] Scientists focus on the possible role of humoral immunity, specifically human B cell subsets and autoantibodies in the pathogenesis of immune checkpoint blockade-induced immune-related adverse events.

Nanoparticles Mediated the Diagnosis and Therapy of Glioblastoma: Bypass or Cross the Blood–Brain Barrier

[Small] Scientists review the application and progress of nanomedicine delivery systems in brain tumors, summarizing the mechanism of nanomaterials crossing the blood-brain barrier. Furthermore, the specific application of nanotechnology in glioblastoma is discussed in depth.

The Role of Chromatin Remodeler SMARCA4/BRG1 in Brain Cancers: A Potential Therapeutic Target

[Oncogene] The authors explore the multifaceted interaction between SMARCA4 and various brain cancer types, highlighting its roles in tumor pathogenesis, the pathways it regulates, and the advances that have been made in understanding the functional relevance of mutations.

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