Review

[Immunological Reviews] The year 2022 marked the entry of “designer” Tregs into the clinic, with exciting potential for application and efficacy in a wide variety of immune-mediated diseases. The authors review the development of designer Tregs through the perspective of three ‘eras' leading up to this.

[Biomaterials Science] Scientists compare Acomys and axolotl skin wound healing and blastema-mediated regeneration by examining their wound healing responses and comparing the expression pattern of matrisome genes, including glycosaminoglycan related genes.

[Life Sciences] Scientists talk about the crosstalk between Hippo and Wnt signaling pathways and the potential microRNAs that might regulate the interplay between the two pathways in breast cancer, which has not been explored earlier.

[Breast Care] The authors summarize two different functions of PGRMC1: (i) to predict the prognosis of breast cancer (BC) patients and (ii) being a possible predictive marker for BC risk during hormone replacement therapy as suggested from in vitro and animal research.

[Placenta] The author highlights the potential for volume electron microscopy to advance our understanding of placental ultrastructure.

[Internal Medicine Journal] The authors focus on the pathogenesis, classification and diagnosis of various endothelial injury syndromes, as well as provides guidance on risk mitigation and treatment.