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Stem Cell-Derived Cardiomyocyte-Like Cells in Myocardial Regeneration

[Tissue Engineering Part B-Reviews] Scientists discuss the current understanding and applications of various stem cell phenotypes to drive the differentiation machinery toward cardiomyocyte-like lineage.

Therapeutic Implications of Cancer Stem Cells in Prostate Cancer

[Cancer Biology & Medicine] The authors discuss the origin, hierarchy, and plasticity of prostate cancer stem cells (PCSCs) and various cellular and metabolic signaling pathways involved in PCSC induction and maintenance.

Antifibrotic Therapy in Nonalcoholic Steatohepatitis: Time for a Human-Centric Approach

[Nature Reviews Gastroenterology & Hepatology] The authors discuss why antifibrotic effects observed in NASH pharmacotherapy trials have been underwhelming and outline potential approaches to improve the likelihood of future clinical success.

Using Human Induced Pluripotent Stem Cell-Derived Liver Cells to Investigate the Mechanisms of Liver Fibrosis In Vitro

[Biochemical Society Transactions] The authors outline the differentiation system of liver non-parenchymal cells from human induced pluripotent stem celld (hiPSCs) and development of in vitro liver disease models using hiPSC-derived liver cells.

Circadian Regulation of Liver Function: From Molecular Mechanisms to Disease Pathophysiology

[Nature Reviews Gastroenterology & Hepatology] Scientists cover the molecular, cellular and organismal aspects of various liver pathologies from a circadian viewpoint, and in particular how circadian dysregulation has a role in the development and progression of these diseases.

Monocyte Regulation by Gut Microbial Signals

[Trends In Microbiology] The authors discuss the newer concepts of regulation of monocyte homeostasis and function by gut microbial signals during steady state and inflammation, and highlight the therapeutic potential of microbial signal-based approaches for modulation in the context of various diseases.

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