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Genotype–Phenotype Landscapes for Immune–Pathogen Coevolution

[Trends In Immunology] The authors describe several approaches that probe different regions of the high-dimensional sequence space and comment on how combinations of these methods may offer novel insight into immune–pathogen coevolution.

Interplay between Endogenous and Exogenous Human Retroviruses

[Trends In Microbiology] Scientists review the impact of infection by exogenous retroviruses on the expression of human endogenous retroviruses (HERVs), the effect of HERVs on the pathogenicity of HIV and human T-cell lymphotropic viruses and on the severity of the diseases caused by them, and the antiviral protection that HERVs can allegedly provide to the host.

Cancer Stem Cell-Derived Exosome-Induced Metastatic Cancer: An Orchestra within the Tumor Microenvironment

[Biochimie] Investigators summarize the characteristic features and functional mechanisms of CSC-derived exosomes/mesenchymal stem cell-exosomes/cancer associated fibroblast-exosomes and their mutual impact on cancer progression and therapy resistance.

Unraveling the Prevalence of Various Signaling Pathways in Non-Small-Cell Lung Cancer: A Review

[Molecular And Cellular Biochemistry] The authors review the current developments in research on various signaling pathways involved in the growth of lung cancer, as well as the underlying mechanisms of the molecules implicated.

Assessing the Generation of Tissue Resident Memory T Cells by Vaccines

[Nature Reviews Immunology] The authors discuss how vaccination strategies aimed at generating a broad and robust T cell response may offer superior protection against pathogens, particularly those that have been observed to mutate rapidly.

Liquid Biopsy on the Horizon in Immunotherapy of Non-Small Cell Lung Cancer: Current Status, Challenges, and Perspectives

[Cell Death & Disease] Scientists review the application of liquid biopsy in predicting the outcomes of immunotherapy in non-small cell lung cancer patients, and discuss the challenges and future directions in this field.

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