Review

[Advanced Drug Delivery Reviews] Combined with advanced imaging technologies and the power of artificial intelligence, organoids provide new insights that bridge experimental models and real-world clinical scenarios.The authors explore research that embodies this technological synergy and how organoids reshape personalized medicine and therapeutics.

[Trends in Molecular Medicine] The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting more than seven million people worldwide.

[Cold Spring Harbor Perspectives In Medicine] As the cancer immunology field is moving toward the analysis of the TIME at the cellular and spatial levels, scientists highlight key studies that revealed previously unappreciated complexity in breast cancer using these technologies.

[Cancer and Metastasis Reviews] Scientists discuss recent insights on clusterin (CLU) in colorectal cancer and its roles in enhancing the plasticity of cells and further consider the implications of CLU as a prospective target for therapeutic intervention.

[Cell Death & Disease] The authors review advancements in utilizing MSCs and their derived extracellular vesicles (EV) for osteoporosis (OP) treatment. It systematically examines the most extensively researched MSC-derived EVs for treating OP, delving not only into the molecular mechanisms of EV-based OP therapy but also conducting a comparative analysis of the strengths and limitations of EVs sourced from various cell origins.

[Journal of Neuroinflammation] Scientists provide the evaluation of the cross-talk between mitochondrial stress and neuroinflammation within the context of stroke.