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RNA N6-Methyladenosine Modifications in Urological Cancers: From Mechanism to Application

[Nature Reviews Urology] Scientists summarize the current evidence indicating that aberrant or dysregulated N6‐methyladenosine (m6A) modification is associated with urological cancer development, progression and prognosis.

Synergistic Therapeutic Strategies and Engineered Nanoparticles for Anti-Vascular Endothelial Growth Factor Therapy in Cancer

[Life Sciences] The authors illustrate the enormous potential of novel synergistic therapeutic strategies and the targeted nanoparticles as an alternate strategy for t treating a variety of tumors employing antiangiogenic therapy.

Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS): A New Axis in Neuronal Degeneration and Regeneration

[Molecular Neurobiology] Mitochondria-Endoplasmic Reticulum Contact Sites (MERCS) are dynamic structures whose physiological interaction is vital to direct life and death of the cell. Dysregulation of this interplay leads to various neurodegenerative disorders.

The Genetic Basis of Autoimmunity Seen through the Lens of T Cell Functional Traits

[Nature Communications] Autoimmune disease heritability is enriched in T cell-specific regulatory regions of the genome. Modern-day T cell datasets now enable association studies between single nucleotide polymorphisms and a myriad of molecular phenotypes.

Liver Fibrosis: Pathological Features, Clinical Treatment and Application of Therapeutic Nanoagents

[Journal Of Materials Chemistry B] The pathological features of liver fibrosis and the current anti-fibrosis drugs in clinical trials are briefly introduced, followed by a detailed introduction of the therapeutic nanoagents for the precise delivery of anti-fibrosis drugs.

Bispecific Antibodies and CAR-T Cells: Dueling Immunotherapies for Large B Cell Lymphomas

[Blood Cancer Journal] Despite recent advances in frontline therapy for diffuse large B-cell lymphoma (DLBCL), at least a third of those diagnosed still will require second or further lines for relapsed or refractory disease.

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