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Asteroid Impact: The Potential of Astrocytes to Modulate Human Neural Networks within Organoids

[Frontiers In Neuroscience] Scientists summarize the potential capability of using organoids to further understand the mechanistic role of astrocytes upon neural networks, including the production of extracellular matrix components and reactive signaling cues.

Astrocytes and Microglia in the Coordination of CNS Development and Homeostasis

[Journal Of Neurochemistry] Investigators focus on astrocytes and microglia highlighting research that documents either suggestive or established coordinated actions by these glial cells in various CNS processes.

Engineered Synthetic Matrices for Human Intestinal Organoid Culture And Therapeutic Delivery

[Advanced Materials] Human intestinal organoids derived from PSCs or adult stem cell biopsies represent a powerful platform to study human development, drug testing, and disease modeling in vitro, and serve as a cell source for tissue regeneration and therapeutic advances in vivo.

Mitigation of Acute Radiation Syndrome (ARS) with Human Umbilical Cord Blood

[International Journal Of Radiation Biology] Scientists discuss acute radiation syndrom and its sub-syndromes, and to highlight recent findings regarding the use of umbilical cord blood for radiation injury.

Purinergic System in Cancer Stem Cells

[Purinergic Signalling] Scientists discuss updated information regarding CSCs in the purinergic system and present evidence supporting the idea that elements of the purinergic system expressed by this subpopulation of the tumor represent attractive pharmacological targets for proposing innovative anti-cancer therapies.

Regeneration of Joint Surface Defects by Transplantation of Allogeneic Cartilage: Application of iPS Cell-Derived Cartilage and Immunogenicity

[Inflammation And Regeneration] The authors review and discuss the immunogenicity of chondrocytes and the efficacy of allogeneic cartilage transplantation, including induced pluripotent stem cell -derived cartilage.

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