ulcerative colitis

[Amino Acids] Varying amounts of undigested or partially digested proteins reach the colon where they are metabolized by the microbiota, resulting in the formation of various compounds. In humans, their accumulation is potentially harmful, and it has been proposed that they could be involved in the development of pathologies such as colorectal cancer and ulcerative colitis.

[Proceedings of the National Academy of Sciences of the United States of America] In murine intestinal epithelium with telomere dysfunction, DNA damage-induced activation of ataxia-telangiectasia mutated (ATM) resulted in ATM-mediated phosphorylation and activation of the YAP1 transcriptional coactivator, which in turn up-regulated pro-IL-18, a pivotal immune regulator in inflammatory bowel disease pathogenesis.

[Molecular Therapy] VBIT-12 treatment of cultured colon cells inhibited the DSS-induced VDAC1 overexpression, oligomerization, and apoptosis.

[Scientific Reports] Scientists investigated the significance of the PD-L1/double-strand break repair pathway using samples from 17 sporadic colorectal cancer and ulcerative colitis (UC) patients with rare UC-associated dysplasia/colitic cancer cases by immunohistochemical analysis.

[Progenity, Inc. (Globe Newswire, Inc.)] Progenity, Inc. announced the formation of its Inflammatory Bowel Disease Clinical Advisory Board. The advisory board includes respected researchers and clinicians who are thought leaders in the research and treatment of inflammatory bowel disease.

[Cell Death & Disease] Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.