Epithelial PBLD Attenuates Intestinal Inflammatory Response and Improves Intestinal Barrier Function by Inhibiting NF-κB Signaling

Researchers analyzed colonic tissue samples from patients with ulcerative colitis (UC) and constructed specific intestinal epithelial phenazine biosynthesis-like domain-containing protein (PBLD)-deficient mice to investigate the role of this protein in UC pathogenesis.