Modelling Hereditary Diffuse Gastric Cancer Initiation Using Transgenic Mouse-Derived Gastric Organoids and Single-Cell Sequencing

Using single‐cell RNA sequencing, researchers explored the transcriptional landscape of a murine organoid model of hereditary diffuse gastric cancer to characterize the impact of CDH1 loss in early tumorigenesis.
[Journal of Pathology]
Dixon, K., Brew, T., Farnell, D., Godwin, T. D., Cheung, S., Chow, C., Ta, M., Ho, G., Bui, M., Douglas, J. M., Campbell, K. R., El‐Naggar, A., Kaurah, P., Kalloger, S. E., Lim, H. J., Schaeffer, D. F., Cochrane, D., Guilford, P., & Huntsman, D. G. (n.d.). Modelling hereditary diffuse gastric cancer initiation using transgenic mouse-derived gastric organoids and single-cell sequencing. The Journal of Pathology, n/a(n/a). https://doi.org/https://doi.org/10.1002/path.5675 Cite
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Vangl2 Promotes the Formation of Long Cytonemes to Enable Distant Wnt/β-Catenin Signaling

Scientists showed that the planar cell polarity protein Vangl2 regulated the distribution of Wnt by cytonemes. They used an organoid formation assay to analyze the requirement for VANGL-dependent WNT cytonemes.
[Nature Communications]
Brunt, L., Greicius, G., Rogers, S., Evans, B. D., Virshup, D. M., Wedgwood, K. C. A., & Scholpp, S. (2021). Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. Nature Communications, 12(1), 2058. https://doi.org/10.1038/s41467-021-22393-9 Cite
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FOXO3 Is a Latent Tumor Suppressor for FOXO3-Positive and Cytoplasmic-Type Gastric Cancer Cells

Treatment of FOXO3-Cyt human gastric cancer-derived organoids with an AKT inhibitor significantly suppressed the survival and proliferation.
[Oncogene]
Tsuji, T., Maeda, Y., Kita, K., Murakami, K., Saya, H., Takemura, H., Inaki, N., Oshima, M., & Oshima, H. (2021). FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells. Oncogene, 1–15. https://doi.org/10.1038/s41388-021-01757-x Cite
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Long Noncoding RNA (lncRNA) EIF3J-DT Induces Chemoresistance of Gastric Cancer via Autophagy Activation

In vitro and in vivo experiments showed that EIF3J-DT activated autophagy and induced drug resistance in gastric cancer cells by targeting ATG14.
[Autophagy]
Luo, Y., Zheng, S., Wu, Q., Wu, J., Zhou, R., Wang, C., Wu, Z., Rong, X., Huang, N., Sun, L., Bin, J., Liao, Y., Shi, M., & Liao, W. (2021). Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation. Autophagy, 0(0), 1–19. https://doi.org/10.1080/15548627.2021.1901204 Cite
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METTL3-Mediated m6a Methylation of SPHK2 Promotes Gastric Cancer Progression by Targeting KLF2

Quantitative real-time PCR, western blot and immunohistochemistry were utilized to detect the expression profiles and prognostic significance of SPHK2 in gastric cancer.
[Oncogene]
Huo, F.-C., Zhu, Z.-M., Zhu, W.-T., Du, Q.-Y., Liang, J., & Mou, J. (2021). METTL3-mediated m 6 A methylation of SPHK2 promotes gastric cancer progression by targeting KLF2. Oncogene, 1–14. https://doi.org/10.1038/s41388-021-01753-1 Cite
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CircFAM73A Promotes the Cancer Stem Cell-Like Properties of Gastric Cancer through the miR-490-3p/HMGA2 Positive Feedback Loop and HNRNPK-Mediated β-Catenin Stabilization

The roles of circFAM73A in gastric cancer cell proliferation, migration, cisplatin resistance, and CSC-like properties were determined by a series of functional experiments both in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research]
Xia, Y., Lv, J., Jiang, T., Li, B., Li, Y., He, Z., Xuan, Z., Sun, G., Wang, S., Li, Z., Wang, W., Wang, L., & Xu, Z. (2021). CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization. Journal of Experimental & Clinical Cancer Research, 40(1), 103. https://doi.org/10.1186/s13046-021-01896-9 Cite
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The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells

Gastric cancer stem-like cells were transfected by hsa-miR-451b inhibitor then researchers used real-time RT-PCR to evaluate its effect on the expression of hsa-miR-451b and two of its direct target genes, stemness markers such as KLF4, SOX2, CD44, OCT3/4 and NANOG genes.
[Biochemical Genetics]
Farahani, D. B., Akrami, H., Moradi, B., Mehdizadeh, K., & Fattahi, M. R. (2021). The Effect of hsa-miR-451b Knockdown on Biological Functions of Gastric Cancer Stem-Like Cells. Biochemical Genetics. https://doi.org/10.1007/s10528-021-10057-8 Cite
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The Role of PKM2 Nuclear Translocation in the Constant Activation of the NF-κB Signaling Pathway in Cancer-Associated Fibroblasts

The authors showed that mesenchymal stem cells differentiated into cancer-associated fibroblasts, induced by the exosomes derived from gastric cancer cells.
[Cell Death & Disease]
Gu, J., Li, X., Zhao, L., Yang, Y., Xue, C., Gao, Y., Li, J., Han, Q., Sun, Z., Bai, C., & Zhao, R. C. (2021). The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts. Cell Death & Disease, 12(4), 1–13. https://doi.org/10.1038/s41419-021-03579-x Cite
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LncRNA AGAP2-AS1 Promotes Cancer Cell Proliferation, Migration and Invasion in Colon Cancer by Forming a Negative Feedback Loop with LINC-PINT

To test the interaction between AGAP2-AS1 and LINC-PINT in colon cancer, overexpression vector or inhibitor of AGAP2-AS1 and LINC-PINT were transfected into RKO and HCT 116 cells.
[Cancer Management and Research]
Ji, L., Chen, S., Gu, L., Wang, J., & Zhang, X. (2021). <p>LncRNA AGAP2-AS1 Promotes Cancer Cell Proliferation, Migration and Invasion in Colon Cancer by Forming a Negative Feedback Loop with LINC-PINT</p>. Cancer Management and Research, 13, 2153–2161. https://doi.org/10.2147/CMAR.S260371 Cite
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miR-19a/miR-96-Mediated Low Expression of KIF26A Suppresses Metastasis by Regulating FAK Pathway in Gastric Cancer

The authors elucidated the roles of kinesin superfamily protein 26A in gastric cancer and its underlying molecular mechanism in regulating tumor invasion and metastasis.
[Oncogene]
Ma, R.-R., Zhang, H., Chen, H.-F., Zhang, G.-H., Tian, Y.-R., & Gao, P. (2021). MiR-19a/miR-96-mediated low expression of KIF26A suppresses metastasis by regulating FAK pathway in gastric cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01610-7 Cite
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Recent Advances in Immune Therapies for Gastric Cancer

The authors summarize the current state of knowledge on immune mechanisms of GC and the status of emerging immunotherapies to treat this aggressive cancer, as well as outline current challenges and directions for future research.
[Cancer Gene Therapy]
Olnes, M. J., & Martinson, H. A. (2021). Recent advances in immune therapies for gastric cancer. Cancer Gene Therapy, 1–11. https://doi.org/10.1038/s41417-021-00310-y Cite
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