Scientists established GC organoids (GCOs) and gradually treated them with higher concentrations of 5-FU. They successfully harvested four 5-FU-resistant GCOs, which were supported by significant changes in the expression of molecules related to 5-FU metabolism. Microarray analysis was peformed using three normal gastric organoids and three pairs of 5-FU-resistant and parental GCOs.
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Ukai, S., Honma, R., Sakamoto, N., Yamamoto, Y., Pham, Q. T., Harada, K., Takashima, T., Taniyama, D., Asai, R., Fukada, K., Naka, K., Tanabe, K., Ohdan, H., & Yasui, W. (2020). Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01492-9 Cite
Luciferase reporter assays results showed that miR-93-5p was a direct target of CA3-AS1 in SGC-7901 and BCG-823. BTG3 was identified as a direct target gene of miR-93-5p. Restore experiments showed that CA3-AS1 upregulated the expression level of BTG3 and inhibited the gastric cancer cells invasion by sponging miR-93-5p.
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Long non-coding RNA small nucleolar host gene 11 (SNHG11) post-transcriptionally upregulated catenin beta 1 and autophagy related 12 through miR-483-3p/miR-1276, while the processing of pre-miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3β ubiquitination through interacting with Cullin 4A to further activate the Wnt/β-catenin pathway.
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LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy: Molecular Therapy. (n.d.). Retrieved October 15, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30545-1 Cite
cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/β-catenin signalling pathway by sequestering miR-17.
LINC00665 expression levels were determined using quantitative polymerase chain reaction analysis with breast cancer tissues and cell lines.
[Cellular & Molecular Biology Letters]
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Lv, M., Mao, Q., Li, J., Qiao, J., Chen, X., & Luo, S. (2020). Knockdown of LINC00665 inhibits proliferation and invasion of breast cancer via competitive binding of miR-3619-5p and inhibition of catenin beta 1. Cellular & Molecular Biology Letters, 25(1), 43. https://doi.org/10.1186/s11658-020-00235-8 Cite
Daiichi Sankyo Company, Limited announced the approval of ENHERTU®, a HER2 directed antibody drug conjugate, in Japan for the treatment of patients with HER2 positive unresectable advanced or recurrent gastric cancer that has progressed after chemotherapy.
[Daiichi Sankyo Ltd.]
ISG12a was found to be expressed at low levels in gastrointestinal cancer, represented by hepatocellular cancer and gastric cancer, and identified as a tumor suppressor that affects clinical prognosis.
[Cellular & Molecular Immunology]
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Deng, R., Zuo, C., Li, Y., Xue, B., Xun, Z., Guo, Y., Wang, X., Xu, Y., Tian, R., Chen, S., Liu, Q., Chen, J., Wang, J., Huang, X., Li, H., Guo, M., Wang, X., Yang, M., Wu, Z., … Zhu, H. (2020). The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Cellular & Molecular Immunology, 1–17. https://doi.org/10.1038/s41423-020-00549-9 Cite
Scientists clarified the potential involvement of long non-coding RNA SNGH3 in the acquisition of cisplatin resistance and stemness in gastric cancer.
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Scientists focused on the role of methionine in the autophagy of gastric cancer stem cells and elaborated its regulatory mechanism.
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Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37: Cell Cycle: Vol 0, No 0. (n.d.). Retrieved September 16, 2020, from https://www.tandfonline.com/doi/abs/10.1080/15384101.2020.1814044?journalCode=kccy20 Cite
The impact of tumor secreted exosomes on immune function in the tumor environment was investigated using exosomes isolated from gastric cancer cell lines MKN-28, MKN-45, and SGC-7901.
Scientists suggested that the tumor immune microenvironment of metastatic tumors was less immunologically active compared to that of primary tumors in gastric cancer patients.
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Son, S.-M., Woo, C. G., Kim, D. H., Yun, H. Y., Kim, H., Kim, H. K., Yang, Y., Kwon, J., Kwon, M., Kim, T.-Y., Kim, H.-D., Koh, J.-Y., Park, S.-H., Shin, E.-C., & Han, H. S. (2020). Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients. Scientific Reports, 10(1), 14293. https://doi.org/10.1038/s41598-020-71340-z Cite