Molecular Biological Analysis of 5-FU-Resistant Gastric Cancer Organoids; KHDRBS3 Contributes to the Attainment of Features of Cancer Stem Cell

Scientists established GC organoids (GCOs) and gradually treated them with higher concentrations of 5-FU. They successfully harvested four 5-FU-resistant GCOs, which were supported by significant changes in the expression of molecules related to 5-FU metabolism. Microarray analysis was peformed using three normal gastric organoids and three pairs of 5-FU-resistant and parental GCOs.
[Oncogene]
Ukai, S., Honma, R., Sakamoto, N., Yamamoto, Y., Pham, Q. T., Harada, K., Takashima, T., Taniyama, D., Asai, R., Fukada, K., Naka, K., Tanabe, K., Ohdan, H., & Yasui, W. (2020). Molecular biological analysis of 5-FU-resistant gastric cancer organoids; KHDRBS3 contributes to the attainment of features of cancer stem cell. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01492-9 Cite
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Long Noncoding RNA CA3-AS1 Suppresses Gastric Cancer Migration and Invasion by Sponging miR-93-5p and Targeting BTG3

Luciferase reporter assays results showed that miR-93-5p was a direct target of CA3-AS1 in SGC-7901 and BCG-823. BTG3 was identified as a direct target gene of miR-93-5p. Restore experiments showed that CA3-AS1 upregulated the expression level of BTG3 and inhibited the gastric cancer cells invasion by sponging miR-93-5p.
[Gene Therapy]
Zhang, X.-Y., Zhuang, H.-W., Wang, J., Shen, Y., Bu, Y.-Z., Guan, B.-G., Xu, F., & Dou, J. (2020). Long noncoding RNA CA3-AS1 suppresses gastric cancer migration and invasion by sponging miR-93-5p and targeting BTG3. Gene Therapy, 1–9. https://doi.org/10.1038/s41434-020-00201-1 Cite
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LncRNA SNHG11 Promotes Gastric Cancer Progression by Activating Wnt/β-Catenin Pathway and Oncogenic Autophagy

Long non-coding RNA small nucleolar host gene 11 (SNHG11) post-transcriptionally upregulated catenin beta 1 and autophagy related 12 through miR-483-3p/miR-1276, while the processing of pre-miR-483/pre-miR-1276 was hindered by SNHG11. SNHG11 induced GSK-3β ubiquitination through interacting with Cullin 4A to further activate the Wnt/β-catenin pathway.
[Molecular Therapy]
LncRNA SNHG11 promotes gastric cancer progression by activating Wnt/β-catenin pathway and oncogenic autophagy: Molecular Therapy. (n.d.). Retrieved October 15, 2020, from https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(20)30545-1 Cite
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Cir-ITCH Inhibits Gastric Cancer Migration, Invasion and Proliferation by Regulating the Wnt/β-Catenin Pathway

cir-ITCH was shown to prevent gastric cancer tumourgenesis through the Wnt/β-catenin signalling pathway by sequestering miR-17.
[Scientific Reports]
Peng, Y., & Wang, H. H. (2020). Cir-ITCH inhibits gastric cancer migration, invasion and proliferation by regulating the Wnt/β-catenin pathway. Scientific Reports, 10(1), 17443. https://doi.org/10.1038/s41598-020-74452-8 Cite
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Knockdown of LINC00665 Inhibits Proliferation and Invasion of Breast Cancer via Competitive Binding of miR-3619-5p and Inhibition of Catenin Beta 1

LINC00665 expression levels were determined using quantitative polymerase chain reaction analysis with breast cancer tissues and cell lines.
[Cellular & Molecular Biology Letters]
Lv, M., Mao, Q., Li, J., Qiao, J., Chen, X., & Luo, S. (2020). Knockdown of LINC00665 inhibits proliferation and invasion of breast cancer via competitive binding of miR-3619-5p and inhibition of catenin beta 1. Cellular & Molecular Biology Letters, 25(1), 43. https://doi.org/10.1186/s11658-020-00235-8 Cite
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ENHERTU® Approved in Japan for the Treatment of Patients with HER2 Positive Metastatic Gastric Cancer

Daiichi Sankyo Company, Limited announced the approval of ENHERTU®, a HER2 directed antibody drug conjugate, in Japan for the treatment of patients with HER2 positive unresectable advanced or recurrent gastric cancer that has progressed after chemotherapy.
[Daiichi Sankyo Ltd.]
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The Innate Immune Effector ISG12a Promotes Cancer Immunity by Suppressing the Canonical Wnt/β-Catenin Signaling Pathway

ISG12a was found to be expressed at low levels in gastrointestinal cancer, represented by hepatocellular cancer and gastric cancer, and identified as a tumor suppressor that affects clinical prognosis.
[Cellular & Molecular Immunology]
Deng, R., Zuo, C., Li, Y., Xue, B., Xun, Z., Guo, Y., Wang, X., Xu, Y., Tian, R., Chen, S., Liu, Q., Chen, J., Wang, J., Huang, X., Li, H., Guo, M., Wang, X., Yang, M., Wu, Z., … Zhu, H. (2020). The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway. Cellular & Molecular Immunology, 1–17. https://doi.org/10.1038/s41423-020-00549-9 Cite
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Long Non-Coding RNA SNHG3, Induced by IL-6/STAT3 Transactivation, Promotes Stem Cell-Like Properties of Gastric Cancer Cells by Regulating the miR-3619-5p/ARL2 Axis

Scientists clarified the potential involvement of long non-coding RNA SNGH3 in the acquisition of cisplatin resistance and stemness in gastric cancer.
[Cellular Oncology]
Sun, B., Han, Y., Cai, H., Huang, H., & Xuan, Y. (2020). Long non-coding RNA SNHG3, induced by IL-6/STAT3 transactivation, promotes stem cell-like properties of gastric cancer cells by regulating the miR-3619-5p/ARL2 axis. Cellular Oncology. https://doi.org/10.1007/s13402-020-00560-2 Cite
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Methionine Represses the Autophagy of Gastric Cancer Stem Cells via Promoting the Methylation and Phosphorylation of RAB37

Scientists focused on the role of methionine in the autophagy of gastric cancer stem cells and elaborated its regulatory mechanism.
[Cell Cycle]
Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37: Cell Cycle: Vol 0, No 0. (n.d.). Retrieved September 16, 2020, from https://www.tandfonline.com/doi/abs/10.1080/15384101.2020.1814044?journalCode=kccy20 Cite
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Immune Suppressed Tumor Microenvironment by Exosomes Derived from Gastric Cancer Cells via Modulating Immune Functions

The impact of tumor secreted exosomes on immune function in the tumor environment was investigated using exosomes isolated from gastric cancer cell lines MKN-28, MKN-45, and SGC-7901.
[Scientific Reports]
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Distinct Tumor Immune Microenvironments in Primary and Metastatic Lesions in Gastric Cancer Patients

Scientists suggested that the tumor immune microenvironment of metastatic tumors was less immunologically active compared to that of primary tumors in gastric cancer patients.
[Scientific Reports]
Son, S.-M., Woo, C. G., Kim, D. H., Yun, H. Y., Kim, H., Kim, H. K., Yang, Y., Kwon, J., Kwon, M., Kim, T.-Y., Kim, H.-D., Koh, J.-Y., Park, S.-H., Shin, E.-C., & Han, H. S. (2020). Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients. Scientific Reports, 10(1), 14293. https://doi.org/10.1038/s41598-020-71340-z Cite
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