gastric cancer

[Cell Death Discovery] Scientists explored the ability of gastric cancer (GC) cell-derived extracellular vesicles (EVs)-mediated microRNA-129-5p/E2F transcription factor 7/mitogen-activated protein kinase/extracellular regulated protein kinase axis to affect the peritoneal metastasis of GC by delivering lncRNA small nucleolar RNA host gene 12.

[Helicobacter] The authors discuss the advantages and limitations of existing in vivo and in vitro models of Helicobacter pylori (H. pylori) infection, and how gastric organoids have been applied to study H. pylori pathogenesis.

[Cell Death & Disease] Researchers explored a prognostic model for the estimation of tumor-associated mortality in gastric cancer (GC) patients and revealed the RNA-binding protein RBMS1 as a candidate promoter gene for GC metastasis by analyzing GOBO and oncomine high-throughput sequencing datasets for 408 GC patients.

[Scientific Reports] Scientists conducted a phosphoproteomic analysis using paired endoscopic biopsy specimens of pre- and post-treatment tumors (Ts) and non-tumor adjacent tissues (NATs) obtained from 4 HER2-positive gastric cancer patients who received trastuzumab-based treatment and from pre-treatment Ts and NATs of 4 HER2-negative gastric cancer patients.

[Cell Death & Disease] Serine/threonine/tyrosine interacting protein (STYX) overexpression facilitated the proliferation and migration in gastric cancer cells, whereas STYX knockdown had the opposite effects.

[Oncogene] To gain novel insights into the downstream signaling pathways of receptor tyrosine kinases specific to diffuse-type gastric cancer (DGC), phosphotyrosine-containing proteins associated with activated fibroblast growth factor receptor 2 were purified through two sequential rounds of immunoprecipitation from the lysates of two DGC cell lines.