Henlius and Accord Healthcare Receive EMA Approval for Zercepac®, Trastuzumab Biosimilar

Shanghai Henlius Biotech, Inc. and Accord Healthcare Limited jointly announced the European Commission has approved Zercepac ® for the treatment of HER2-positive early breast cancer, HER2-positive metastatic breast cancer and HER2-positive metastatic gastric cancer.
[Henlius]
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CXCL5 Promotes Gastric Cancer Metastasis by Inducing Epithelial-Mesenchymal Transition and Activating Neutrophils

The authors report that the expression of CXCL5 was elevated in tumor tissues and positively associated with lymphatic metastasis and tumor differentiation.
[Oncogenesis]
Mao, Z., Zhang, J., Shi, Y., Li, W., Shi, H., Ji, R., … Zhang, X. (2020). CXCL5 promotes gastric cancer metastasis by inducing epithelial-mesenchymal transition and activating neutrophils. Oncogenesis, 9(7), 1–14. https://doi.org/10.1038/s41389-020-00249-z Cite
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Exosomal MiR‐500a‐3p Promotes Cisplatin Resistance and Stemness via Negatively Regulating FBXW7 in Gastric Cancer

Researchers found that microRNA‐500a‐3p was highly expressed in cisplatin resistant gastric cancer cells and their secreted exosomes than that in the corresponding parental cells.
[Journal of Cellular and Molecular Medicine]
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CDK5RAP3 as Tumour Suppressor Negatively Regulates Self-Renewal and Invasion and is Regulated by ERK1/2 Signalling in Human Gastric Cancer

Results demonstrated that CDK5 regulatory subunit-associated protein 3 was suppressed by extracellular-related kinase signalling and negatively regulated the self-renewal and epithelial-to-mesenchymal transition of gastric cancer stem-like cells.
[British Journal of Cancer]
Abstract

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SOX18 Promotes Gastric Cancer Metastasis through Transactivating MCAM and CCL7

Investigators defined a C-C motif chemokine ligand 7-CCR1-SRY-box transcription factor positive feedback loop that played a pivotal role in GC metastasis
[Oncogene]
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miR-503-5p Inhibits Colon Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Directly Downregulating VEGF-A

Scientists observed considerable downregulation of miR-503-5p expression in colon cancer cells and tissues and significant correlation with the TNM stage, differentiation grade and lymph node metastasis of colon cancer. Overexpression of miR-503-5p promoted the apoptosis and G1 arrest of colon cancer cells, and inhibited migration, proliferation, invasion and colony formation.
[Gene Therapy]
Abstract

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First-in-Class Inhibitors of Oncogenic CHD1L with Preclinical Activity against Colorectal Cancer

Researchers characterized the clinicopathological link between CHD1L and colorectal cancer (CRC), determined the mechanism(s) by which CHD1L drove malignant CRC, and discovered the first inhibitors with potential for novel treatments for CRC.
[Molecular Cancer therapeutics]
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Angiogenic Cytokines Can Reflect the Synovitis Severity and Treatment Response to Biologics in Rheumatoid Arthritis

To determine the clinical significance of angiogenic cytokines in rheumatoid arthritis (RA), the levels of pro-angiogenic cytokines, including VEGF, placenta growth factor, and IL-6, were measured in the synovial fluid and sera of RA patients using ELISA.
[Experimental and Molecular Medicine]
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