Transferrin Receptor 1 Promotes the Fibroblast Growth Factor Receptor-Mediated Oncogenic Potential of Diffused-Type Gastric Cancer

To gain novel insights into the downstream signaling pathways of receptor tyrosine kinases specific to diffuse-type gastric cancer (DGC), phosphotyrosine-containing proteins associated with activated fibroblast growth factor receptor 2 were purified through two sequential rounds of immunoprecipitation from the lysates of two DGC cell lines.