Epithelial Sensing of Microbiota-Derived Signals

The authors highlight the pathways by which intestinal epithelial cells sense microbiota-derived signals and the necessity of these detection pathways in maintaining epithelial barrier integrity.
[Genes & Immunity]
Eshleman, E. M., & Alenghat, T. (2021). Epithelial sensing of microbiota-derived signals. Genes & Immunity, 1–10. https://doi.org/10.1038/s41435-021-00124-w Cite
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Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin-Gut Axis Communication

Scientists studied the role of exopolysaccharides produced by lactic acid bacteria identified as Lactobacillus plantarum HY7714 in regulating tight junctions in intestinal epithelial cells and increasing moisture retention in human dermal fibroblasts cells.
[Molecules]
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Restitution of Epithelial Cells during Intestinal Mucosal Wound Healing: The Effect of a Polysaccharide from the Sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden

Researchers investigated the effect and mechanism of β-glucan prepared from Lignosus rhinocerotis using an enzymatic method on epithelial restitution during intestinal mucosal damage.
[Journal of Ethnopharmacology]
Veeraperumal, S., Qiu, H.-M., Tan, C.-S., Ng, S.-T., Zhang, W., Tang, S., Cheong, K.-L., & Liu, Y. (2021). Restitution of epithelial cells during intestinal mucosal wound healing: the effect of a polysaccharide from the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden. Journal of Ethnopharmacology, 114024. https://doi.org/10.1016/j.jep.2021.114024 Cite
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Differential Protection by Anthocyanin-Rich Bilberry Extract and Resveratrol against Lipid Micelle-Induced Oxidative Stress and Monolayer Permeability in Caco-2 Intestinal Epithelial Cells

In a Caco-2 cell model of dietary fat-induced intestinal epithelial cell cytotoxicity, oxidative stress and barrier impairment, researchers investigated the relative protection afforded by an anthocyanin-rich bilberry extract or resveratrol.
[Food & Function]
Ershad, M., Shigenaga, M. K., & Bandy, B. (2021). Differential protection by anthocyanin-rich bilberry extract and resveratrol against lipid micelle-induced oxidative stress and monolayer permeability in Caco-2 intestinal epithelial cells. Food & Function. https://doi.org/10.1039/D0FO02377A Cite
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Signaling Pathways in Intestinal Homeostasis and Colorectal Cancer: KRAS at Centre Stage

Scientists summarize the signaling pathways contributing to intestinal cell fates and homeostasis functions, focusing on intestinal stem cell proliferation, cell junction formation, remodeling, hypoxia, the impact of intestinal microbiota, the immune system, inflammation, and metabolism.
[Cell Communication and Signaling]
Ternet, C., & Kiel, C. (2021). Signaling pathways in intestinal homeostasis and colorectal cancer: KRAS at centre stage. Cell Communication and Signaling, 19(1), 31. https://doi.org/10.1186/s12964-021-00712-3 Cite
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Plectin Ensures Intestinal Epithelial Integrity and Protects Colon against Colitis

Mechanistically, plectin deficiency in intestinal epithelial cell led to aberrant keratin filament network organization and the formation of dysfunctional hemidesmosomes and intercellular junctions.
[Mucosal Immunology]
Krausova, A., Buresova, P., Sarnova, L., Oyman-Eyrilmez, G., Skarda, J., Wohl, P., Bajer, L., Sticova, E., Bartonova, L., Pacha, J., Koubkova, G., Prochazka, J., Spörrer, M., Dürrbeck, C., Stehlikova, Z., Vit, M., Ziolkowska, N., Sedlacek, R., Jirak, D., … Gregor, M. (2021). Plectin ensures intestinal epithelial integrity and protects colon against colitis. Mucosal Immunology, 1–12. https://doi.org/10.1038/s41385-021-00380-z Cite
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MALAT1 Maintains the Intestinal Mucosal Homeostasis in Crohn’s Disease via the miR-146b-5p-CLDN11/NUMB Pathway

Effects of intestinal epithelial cells transfected with metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) lentiviruses and Smart Silencer, on monolayer permeability and apical junction complex proteins were analyzed.
[Journal of Crohns & Colitis]
Li, Y., Zhu, L., Chen, P., Wang, Y., Yang, G., Zhou, G., Li, L., Feng, R., Qiu, Y., Han, J., Chen, B., He, Y., Zeng, Z., Chen, M., & Zhang, S. (2021). MALAT1 maintains the intestinal mucosal homeostasis in Crohn’s disease via the miR-146b-5p-CLDN11/NUMB pathway. Journal of Crohn’s and Colitis, jjab040. https://doi.org/10.1093/ecco-jcc/jjab040 Cite
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Epithelial Production of Elastase Is Increased in Inflammatory Bowel Disease and Causes Mucosal Inflammation

Researchers revealed that epithelial cells are a major source of elastolytic activity in healthy human colonic tissues and this activity is greatly increased in Inflammatory Bowel Disease patients, both in diseased and distant sites of inflammation.
[Mucosal Immunology]
Motta, J.-P., Rolland, C., Edir, A., Florence, A.-C., Sagnat, D., Bonnart, C., Rousset, P., Guiraud, L., Quaranta-Nicaise, M., Mas, E., Bonnet, D., Verdu, E. F., McKay, D. M., Buscail, E., Alric, L., Vergnolle, N., & Deraison, C. (2021). Epithelial production of elastase is increased in inflammatory bowel disease and causes mucosal inflammation. Mucosal Immunology, 1–12. https://doi.org/10.1038/s41385-021-00375-w Cite
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Effect of Roasted Peanut Allergen Ara H 3 Protein on the Sensitization of Caco-2 Cells

To evaluate the sensitization mechanism of peanut allergen Ara h 3, Caco‐2 cells as the model, which has the similar structure and function to differentiated small intestinal epithelial cells.
[Journal of the Science of Food and Agriculture]
Wang, S., Sun, X., Wang, M., Deng, Z., Niu, B., & Chen, Q. (n.d.). Effect of roasted peanut allergen Ara h 3 protein on the sensitization of Caco-2 cells. Journal of the Science of Food and Agriculture, n/a(n/a). https://doi.org/https://doi.org/10.1002/jsfa.11180 Cite
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EGFL7 as a Novel Therapeutic Candidate Regulates Cell Invasion and Anoikis in Colorectal Cancer through PI3K/AKT Signaling Pathway

Epidermal growth factor-like domain-containing protein 7 (EGFL7) was upregulated in several colorectal cancer cell lines as compared with normal intestinal epithelial cell line HIEC. Transfection of EGFL7 siRNA significantly decreased cell proliferation and invasion capacity of SW620 and LoVo cells.
[International Journal of Clinical Oncology]
Juan, Z., Dake, C., Tanaka, K., & Shuixiang, H. (2021). EGFL7 as a novel therapeutic candidate regulates cell invasion and anoikis in colorectal cancer through PI3K/AKT signaling pathway. International Journal of Clinical Oncology. https://doi.org/10.1007/s10147-021-01888-x Cite
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Colitis-Linked to Endoplasmic Reticulum Stress Induces Trypsin Activity Affecting Epithelial Functions

The impact of ER stress induced by Thapsigargin on serine protease secretion was studied using either human intestinal cells lines or organoids.
[Journal of Crohn’s and Colitis]
Tapias, N. S., Denadai-Souza, A., Rolland-Fourcade, C., Quaranta-Nicaise, M., Blanpied, C., Marcellin, M., Edir, A., Rolland, C., Cirillo, C., Dietrich, G., Alric, L., Portier, G., Kirzin, S., Bonnet, D., Mas, E., Burlet-Schiltz, O., Deraison, C., Bonnart, C., Vergnolle, N., & Barreau, F. (2021). Colitis-linked to endoplasmic reticulum stress induces trypsin activity affecting epithelial functions. Journal of Crohn’s and Colitis, jjab035. https://doi.org/10.1093/ecco-jcc/jjab035 Cite
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