ERK/MAPK Signaling Is Essential for Intestinal Development through Wnt Pathway Modulation

Scientists found that deletion of Erk1/2 in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation and migration, expansion of intestinal stem cells and formation of polyp-like structures, leading to postnatal death.
[Development]
ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/early/2020/07/30/dev.185678 Cite
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Berberine Inhibits Intestinal Epithelial Barrier Dysfunction in Colon Caused by Peritoneal Dialysis Fluid by Improving Cell Migration

In the wound healing assay, berberine exhibited the ability to promote cell migration, indicating that berberine could probably recover the function of intestinal epithelial cells when the intestinal epithelial barrier was damaged by the peritoneal dialysis fluid.
[Journal of Ethnopharmacology]
Zhang, D., Jiang, L., Wang, M., Jin, M., Zhang, X., Liu, D., Wang, Z., Yang, L., & Xu, X. (2020). Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration. Journal of Ethnopharmacology, 113206. https://doi.org/10.1016/j.jep.2020.113206 Cite
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Microbiota-Derived Metabolite Promotes HDAC3 Activity in the Gut

Intestinal exposure to inositol trisphosphate and phytate ingestion both promoted recovery following intestinal damage. Remarkably, inositol trisphosphate also induced growth of patient-derived intestinal organoids, stimulated HDAC3-dependent proliferation, and countered butyrate inhibition of colonic growth.
[Nature]
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Cell Death in the Gut Epithelium and Implications for Chronic Inflammation

This review discusses the underlying molecular and cellular underpinnings that control programmed cell death in intestinal epithelial cells, which emerge during intestinal diseases.
[Nature Reviews Gastroenterology & Hepatology]
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Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells upon Endoplasmic Reticulum Stress

Scientists studied the pathways that regulate activating transcription factor 6 and its role for inflammation in intestinal epithelial cells.
[Gastroenterology]
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Alginate Oligosaccharides Enhance Small Intestine Cell Integrity and Migration Ability

Investigators explored the effects of alginate oligosaccharides on the integrity and migration of small intestine cells using swine intestinal epithelial IPEC-J2 cells.
[Life Sciences]
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Cathelicidin-Mediated Lipopolysaccharide Signaling via Intracellular TLR4 in Colonic Epithelial Cells Evokes CXCL8 Production

In addition to its known microbicidal action, cathelicidin had a unique pathogen-sensing role, facilitating LPS-mediated intestinal responses, including the production of CXCL8/CXCL1 that would contribute to an integrated tissue response to recruit neutrophils during colitis.
[Gut Microbes]
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Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T Cell-Induced, and Infectious Colitis in Mice

In mice with dextran sodium sulfate or T cell-induced colitis, loss of histocompatibility complex class II (MHCII) from Intestinal epithelial cells reduced but does not eliminated mucosal inflammation. However, in mice with C rodentium-induced colitis, loss of MHCII reduced bacterial clearance by decreasing binding of IgA to commensal and pathogenic bacteria.
[Gastroenterology]
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Epithelial-Derived Gasdermin D Mediates Nonlytic IL-1β Release during Experimental Colitis

Scientists report a nonpyroptotic role of full-length Gasdermin D in guiding the release of IL-1β–containing small extracellular vesicles from intestinal epithelial cells .
[Journal of Clinical Investigation]
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CD47 Is a Negative Regulator of Intestinal Epithelial Cell Self-Renewal Following Dss-Induced Experimental Colitis

Scientists revealed CD47 as a negative regulator in intestinal epithelial cell renewal during colitis through downregulating OSKM transcriptional factors.
[Scientific Reports]
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Exosomes Transfer miRNAas from Cell-To-Cell to Inhibit Autophagy During Infection with Crohn’s Disease-Associated Adherent-Invasive E. coli

Investigators showed that upon Adherent-invasive E. coli (AIEC) infection, intestinal epithelial cells(IECs) secreted exosomes that could transfer specific miRNAs to recipient IECs, inhibiting autophagy-mediated clearance of intracellular AIEC.
[Gut Microbes]
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Wnt-Driven LARGE2 Mediates Laminin-Adhesive O-Glycosylation in Human Colonic Epithelial Cells and Colorectal Cancer

Investigators revealed that Wnt activity triggered the expression of the gene, LARGE2, which in turn mediated the laminin- adhesive O-glycosylation of α-DG. They found abnormally increased cellular adhesion to laminin during Wnt-driven cancer progression.
[Cell Communication and Signaling]
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