Aluminum Induced Intestinal Dysfunction via Mechanical, Immune, Chemical and Biological Barriers

Aluminum treatment can regulate intestinal composition and bio-enzyme activity, impairing the function of chemical barrier.
[Chemosphere]
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Integrated Analysis of Dysregulated microRNA and mRNA Expression in Intestinal Epithelial Cells Following Ethanol Intoxication and Burn Injury

Investigators performed an integrated analysis of miRNA and RNA sequencing data to identify a network of interactions within small intestinal epithelial cells (IECs) which could promote gut barrier disruption.
[Scientific Reports]
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Mitochondrial and Glycolytic Extracellular Flux Analysis Optimization for Isolated Pig Intestinal Epithelial Cells

The authors developed a method to isolate viable intestinal epithelial cells, suitable to faithfully measure their metabolic function by determining extracellular glycolytic and mitochondrial flux.
[Scientific Reports]
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Epithelial Argininosuccinate Synthetase Is Dispensable for Intestinal Regeneration and Tumorigenesis

Scientists investigated the function of argininosuccinate synthetase (ASS1) in the gut epithelium during tissue regeneration and tumorigenesis, using intestinal epithelial conditional Ass1 knockout mice and organoids, and tissue specimens from colorectal cancer patients.
[Cell Death & Disease]
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The ATP-Hydrolyzing Ectoenzyme E-NTPD8 Attenuates Colitis through Modulation of P2X4 Receptor–Dependent Metabolism in Myeloid Cells

The molecular mechanism by which microbiota-derived ATP in the colon is regulated remains poorly understood. Researchers showed that E-NTPD8 was highly expressed in large-intestinal epithelial cells and hydrolyzed microbiota-derived luminal ATP.
[Proceedings of the National Academy of Sciences of the United States of America]
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Gut Epithelial IL-27 Confers Intestinal Immunity through the Induction of Intraepithelial Lymphocytes

Researchers revealed that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 confered barrier immunity by inducing a specific intraepithelial lymphocyte subset and further suggested that IL-27 produced by different cell types played distinct roles in maintaining intestinal homeostasis.
[Journal of Experimental Medicine]
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KIR3DS1 Directs NK Cell-Mediated Protection against Human Adenovirus Infections

To decipher immune recognition of human adenoviruse (HAdV) infection and determine new targets for immune-mediated control, researchers used an HAdV infection 3D organoid system, based on primary human intestinal epithelial cells.
[Science Immunology]
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TNF-α Synergises with IFN-γ to Induce Caspase-8-JAK1/2-STAT1-Dependent Death of Intestinal Epithelial Cells

Through unbiased kinome RNAi and drug repurposing screens scientists identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human intestinal epithelial cells by IFN-γ/TNF-α.
[Cell Death & Disease]
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Genetic and Epigenetic Basis of Hepatoblastoma Diversity

Scientists performed an integrative genomic profiling of 163 pediatric liver tumors based on the data acquired from a cohort study. DNA methylation profiling revealed that classical hepatoblastomas were characterized by the specific hypomethylated enhancers, which were enriched with binding sites for ASCL2, a regulatory transcription factor for definitive endoderm in Wnt-pathway.
[Nature Communications]
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Serum Amyloid A Delivers Retinol to Intestinal Myeloid Cells to Promote Adaptive Immunity

Researchers showed that low-density lipoprotein receptor—related protein 1 mediated cell surface binding and the endocytosis of serum amyloid A-retinol complexes in cultured cells.
[Science]
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TKT Maintains Intestinal ATP Production and Inhibits Apoptosis-Induced Colitis

How transketolase (TKT) functions in the intestinal epithelium remains to be elucidated. To address this question, researchers specifically deleted TKT in intestinal epithelial cells.
[Cell Death & Disease]
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