Plumericin was evaluated for its ability to improve barrier function and to reduce apoptotic parameters during inflammation, both in intestinal epithelial cells, and in an animal experimental model of 2, 4, 6-dinitrobenzene sulfonic acid-induced colitis.
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Rapa, S. F., Di Paola, R., Cordaro, M., Siracusa, R., D’Amico, R., Fusco, R., Autore, G., Cuzzocrea, S., Stuppner, H., & Marzocco, S. (2021). Plumericin Protects against Experimental Inflammatory Bowel Disease by Restoring Intestinal Barrier Function and Reducing Apoptosis. Biomedicines, 9(1), 67. https://doi.org/10.3390/biomedicines9010067 Cite
The authors summarize the latest scientific literature on the involvement of this pathway in inflammatory bowel disease (IBD) from the following perspectives that account for the IBD pathogenesis: intestinal epithelial cell regeneration, immune regulation, gut microbiota, and angiogenesis.
[Cell Death & Disease]
Researchers took advantage of induced pluripotent stem cells to develop an induced human UC-derived organoid model and compared it with the induced human normal organoid model.
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Sarvestani, S. K., Signs, S., Hu, B., Yeu, Y., Feng, H., Ni, Y., Hill, D. R., Fisher, R. C., Ferrandon, S., DeHaan, R. K., Stiene, J., Cruise, M., Hwang, T. H., Shen, X., Spence, J. R., & Huang, E. H. (2021). Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity. Nature Communications, 12(1), 262. https://doi.org/10.1038/s41467-020-20351-5 Cite
Landos Biopharma, announced positive results from a first-in-patients 12-week Phase II proof-of-concept trial of BT-11, a novel, orally administered, gut-restricted LANCL2 modulator in patients with mild to moderate ulcerative colitis. By activating the LANCL2 pathway and modulating the interactions between immunological and metabolic signals in immune cells, BT-11 is designed to create a favorable regulatory microenvironment in the gut.
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Scientists review different organoid-based ex vivo models that are currently available, and benchmark their suitability and limitations for specific research questions.
[Journal of Crohns & Colitis]
Scientists sought to delineate tissue-specific contributions of Selenoprotein P (SELENOP) to intestinal inflammatory carcinogenesis and define clinical context. SELENOP loss was assessed in human ulcerative colitis organoids, and expression was queried in human and adult UC samples.
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Colonic epithelial-derived Selenoprotein P is the source for antioxidant-mediated protection in colitis-associated cancer - Gastroenterology. (n.d.). Retrieved January 5, 2021, from https://www.gastrojournal.org/article/S0016-5085(20)35623-7/pdf?referrer=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F Cite
Researchers demonstrated an important role for RNF186 in macroautophagy/autophagy activation in colonic epithelial cells and intestinal homeostasis. Mechanistically, RNF186 acts as an E3 ubiquitin-protein ligase for EPHB2 and regulates the ubiquitination of EPHB2.
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Bacainn Therapeutics, Inc. announced the successful completion of the company’s Phase I, first-in-human clinical trial of BT051, a novel, orally administered, gut-selective inhibitor of migration and activation of neutrophils.
[Bacainn Therapeutics, Inc. (Business Wire, Inc.)]
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Investigators report that endothelial cell protein C receptor was expressed in the colon epithelial cells, CD11c+, and CD21+/CD35+ myeloid cells surrounding the crypts in the colon mucosa.
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Paneth cells are located at the base of small intestinal crypts and secrete the α‐defensins, human α‐defensin 5 and human α‐defensin 6 in response to bacterial, cholinergic and other stimuli.
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Intestine-specific Ndrg2 deficiency mice were subjected to DSS- or TNBS-induced colitis, and AOM-DSS-induced colitis-associated tumour. HT29 cells, Caco2 cells, primary intestinal epithelial cells from Ndrg2ΔIEC mice, mouse embryo fibroblasts from systemic Ndrg2 knockout mice, HEK293 cells and human UC and DC specimens were used to investigate NDRG2 function in colitis and colitis-associated tumour.
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