Microbial Signals, MyD88, and Lymphotoxin Drive TNF-Independent Intestinal Epithelial Tissue Damage

Researchers showed that TNF-independent intestinal epithelial cells death after A20 and Abin-1 deletion was rescued by germ-free derivation or deletion of MyD88, while deletion of Trif provided only partial protection.
[Journal of Clinical Investigation]
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Canonical TGFβ Signaling Induces Collective Invasion in Colorectal Carcinogenesis through a Snail1- and Zeb1-Independent Partial EMT

The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.
[Oncogene]
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Oncogenic Potential of BEST4 in Colorectal Cancer via Activation of PI3K/Akt Signaling

BEST4 is a member of the bestrophin protein family that plays a critical role in human intestinal epithelial cells. Scientists investigated the role and clinical significance of BEST4 in CRC.
[Oncogene]
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An In Vitro Chronic Damage Model Impairs Inflammatory and Regenerative Responses in Human Colonoid Monolayers

Investigators developed a chronic-injury model in human colonoid monolayers by repeated rounds of air-liquid interface and submerged culture.
[Cell Reports]
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Ex Vivo and In Vivo Suppression of SARS-CoV-2 with Combinatorial AAV-RNAi Expression Vectors

Researchers comprehensively illustrated the capacity of adeno-associated virus (AAV) vectors co-expressing a cocktail of three short hairpin RNAs directed against the SARS-CoV-2 RdRp and N genes as versatile and effective antivirals.
[Molecular Therapy]
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CDC42 Controlled Apical-Basal Polarity Regulates Intestinal Stem Cell to Transit Amplifying Cell Fate Transition via YAP-EGF-mTOR Signaling

The authors found that CDC42 loss initiated in the intestinal stem cell caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.
[Cell Reports]
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Robust Differentiation of Human Enteroendocrine Cells from Intestinal Stem Cells

Investigator employed small molecule targeting of the endocannabinoid receptor signaling pathway, JNK, and FOXO1, known to mediate endodermal development and/or hormone production, together with directed differentiation of human ISCs from the duodenum and rectum.
[Nature Communications]
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ID2 Controls Differentiation of Enteroendocrine Cells in Mouse Small Intestine

To assess the functions of ID2 in the adult mouse small intestine, investigators used single-cell RNA sequencing, genetically modified mice, and organoid assays.
[Acta Physiologica]
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Ionizing Radiation Alters Organoid Forming Potential and Replenishment Rate in a Dose/Dose-Rate Dependent Manner

Researchers assessed the response to radiation dose and dose-rate by measuring both organoid-forming potential and the percentage of stem cells in the crypts.
[Journal of Radiation Research]
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Hydroxysafflor Yellow a Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer Cells through the PPARγ/PTEN/Akt Signaling Pathway

Researchers clarified the role of hydroxysafflor yellow A in inhibiting colorectal cancer in vitro and the underlying mechanisms.
[Bioengineered]
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All Layers Matter: Innovative Three-Dimensional Epithelium-Stroma-Endothelium Intestinal Model for Reliable Permeability Outcomes

Researchers developed an advanced three-dimensional in vitro intestinal model to test absorption in a more reliable manner, by better mimicking the native environment.
[Journal of Controlled Release]
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