intestinal cells

[Oncogene] Scientists performed a synthetic lethal drug screening with SMAD4-isogenic colorectal cancer cells and found that aurora kinase A inhibition is synthetic lethal with SMAD4 loss.

[Environmental Toxicology] Researchers investigated the effects of glyphosate-based herbicides on antioxidant capacity, inflammatory cytokines, and autophagy of porcine intestinal epithelial cells IPEC-J2 and its molecular mechanism.

[Stem Cell Reports] Using single-cell transcriptomics, investigators observed that OLFM4, a NOTCH target gene present in intestinal stem cells, was first expressed at 13 weeks post-conception in the developing human intestine and increased over time.

[American Journal of Physiology-Gastrointestinal and Liver Physiology] To explore a role for reflux-induced epithelial-mesenchymal plasticity in Barrett's esophagus, scientists established and characterized human Barrett's organoids, and sought evidence of epithelial-mesenchymal plasticity after treatment with acidic bile salts

[Toxicology Letters] Small intestinal organoids were used to assess if arsenic exposure would also impair intestinal stem cell differentiation. No changes in markers of differentiated epithelial cells were seen.

[Nature Communications] Scientists investigated early infection events using both Trichuris muris infections of mice and murine caecaloids, the first in vitro system for whipworm infection and organoid model for live helminths.