Tag results:

intestinal cells

Aurora Kinase a Inhibition Induces Synthetic Lethality in SMAD4-Deficient Colorectal Cancer Cells via Spindle Assembly Checkpoint Activation

[Oncogene] Scientists performed a synthetic lethal drug screening with SMAD4-isogenic colorectal cancer cells and found that aurora kinase A inhibition is synthetic lethal with SMAD4 loss.

Glyphosate-Based Herbicides Induces Autophagy in IPEC-J2 Cells and the Intervention of N-acetylcysteine

[Environmental Toxicology] Researchers investigated the effects of glyphosate-based herbicides on antioxidant capacity, inflammatory cytokines, and autophagy of porcine intestinal epithelial cells IPEC-J2 and its molecular mechanism.

Acquisition of NOTCH Dependence Is a Hallmark of Human Intestinal Stem Cell Maturation

[Stem Cell Reports] Using single-cell transcriptomics, investigators observed that OLFM4, a NOTCH target gene present in intestinal stem cells, was first expressed at 13 weeks post-conception in the developing human intestine and increased over time.

A Human Barrett’s Esophagus Organoid System Reveals Epithelial-Mesenchymal Plasticity Induced by Acid and Bile Salts

[American Journal of Physiology-Gastrointestinal and Liver Physiology] To explore a role for reflux-induced epithelial-mesenchymal plasticity in Barrett's esophagus, scientists established and characterized human Barrett's organoids, and sought evidence of epithelial-mesenchymal plasticity after treatment with acidic bile salts

Arsenic Exposure Impairs Intestinal Stromal Cells

[Toxicology Letters] Small intestinal organoids were used to assess if arsenic exposure would also impair intestinal stem cell differentiation. No changes in markers of differentiated epithelial cells were seen.

Defining the Early Stages of Intestinal Colonization by Whipworms

[Nature Communications] Scientists investigated early infection events using both Trichuris muris infections of mice and murine caecaloids, the first in vitro system for whipworm infection and organoid model for live helminths.