Epithelial Sensing of Microbiota-Derived Signals

The authors highlight the pathways by which intestinal epithelial cells sense microbiota-derived signals and the necessity of these detection pathways in maintaining epithelial barrier integrity.
[Genes & Immunity]
Eshleman, E. M., & Alenghat, T. (2021). Epithelial sensing of microbiota-derived signals. Genes & Immunity, 1–10. https://doi.org/10.1038/s41435-021-00124-w Cite
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white Regulates Proliferative Homeostasis of Intestinal Stem Cells during Aging in Drosophila

Intestinal stem cell (ISC)-specific inhibition of white suppressed aging-induced ISC dysregulation and prolonged lifespan.
[Nature Metabolism]
Sasaki, A., Nishimura, T., Takano, T., Naito, S., & Yoo, S. K. (2021). white regulates proliferative homeostasis of intestinal stem cells during ageing in Drosophila. Nature Metabolism, 1–12. https://doi.org/10.1038/s42255-021-00375-x Cite
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Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin-Gut Axis Communication

Scientists studied the role of exopolysaccharides produced by lactic acid bacteria identified as Lactobacillus plantarum HY7714 in regulating tight junctions in intestinal epithelial cells and increasing moisture retention in human dermal fibroblasts cells.
[Molecules]
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MiR-142-3p Targets HMGA2 and Suppresses Breast Cancer Malignanc

The authors demonstrated that the miRNA miR-142-3p directly targeted the 3′ untranslated region of HMGA2, which encoded an onco-embryonic protein that was overexpressed in most cancers, including breast cancer.
[Life Sciences]
Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C.-S., & Baradaran, B. (2021). MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy. Life Sciences, 119431. https://doi.org/10.1016/j.lfs.2021.119431 Cite
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Camel Whey Protein Hydrolysates Induced G2/M Cellcycle Arrest in Human Colorectal Carcinoma

Peptides from milk proteins is gaining popularity in various therapeutics including human cancer. Researchers investigated the anti-cancerous and anti-inflammatory properties of camel whey protein hydrolysates
[Scientific Reports]
Murali, C., Mudgil, P., Gan, C.-Y., Tarazi, H., El-Awady, R., Abdalla, Y., Amin, A., & Maqsood, S. (2021). Camel whey protein hydrolysates induced G2/M cellcycle arrest in human colorectal carcinoma. Scientific Reports, 11(1), 7062. https://doi.org/10.1038/s41598-021-86391-z Cite
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Suppression of Elevated Cdc42 Activity Promotes the Regenerative Potential of Aged Intestinal Stem Cells

Elevation of Cdc42 activity in young animals by genetic means causes premature ISC aging, whereas pharmacological suppression of elevated Cdc42 activity restores organoid formation potential in vitro.
[iScience]
Nalapareddy, K., Hassan, A., Sampson, L., Zheng, Y., & Geiger, H. (2021). Suppression of elevated Cdc42 activity promotes the regenerative potential of aged intestinal stem cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102362 Cite
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Porcine Colonoids and Enteroids Keep the Memory of Their Origin during Regeneration

Colonoid and enteroid gene expression signatures were more similar to those found for the tissues of their origin than to each other.
[American Journal of Physiology-Cell Physiology]
Barnett, A. M., Mullaney, J. A., Hendriks, C., Le Borgne, L., McNabb, W. C., & Roy, N. (2021). Porcine colonoids and enteroids keep the memory of their origin during regeneration. American Journal of Physiology-Cell Physiology. https://doi.org/10.1152/ajpcell.00420.2020 Cite
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The Murine Intestinal Stem Cells Are Highly Sensitive to the Modulation of the T3/TRα1-Dependent Pathway

By using ex vivo 3D organoid cultures and molecular approaches scientists observed early responses to T3 involving the T3-metabolizing enzyme Dio1 and the transporter Mct10, accompanied by a complex response of stem cell- and progenitor-enriched genes.
[Development]
Godart, M., Frau, C., Farhat, D., Giolito, M. V., Jamard, C., Nevé, C. L., Freund, J.-N., Penalva, L. O., Sirakov, M., & Plateroti, M. (2021). The murine intestinal stem cells are highly sensitive to the modulation of the T3/TRα1-dependent pathway. Development. https://doi.org/10.1242/dev.194357 Cite
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Restitution of Epithelial Cells during Intestinal Mucosal Wound Healing: The Effect of a Polysaccharide from the Sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden

Researchers investigated the effect and mechanism of β-glucan prepared from Lignosus rhinocerotis using an enzymatic method on epithelial restitution during intestinal mucosal damage.
[Journal of Ethnopharmacology]
Veeraperumal, S., Qiu, H.-M., Tan, C.-S., Ng, S.-T., Zhang, W., Tang, S., Cheong, K.-L., & Liu, Y. (2021). Restitution of epithelial cells during intestinal mucosal wound healing: the effect of a polysaccharide from the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden. Journal of Ethnopharmacology, 114024. https://doi.org/10.1016/j.jep.2021.114024 Cite
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Differential Protection by Anthocyanin-Rich Bilberry Extract and Resveratrol against Lipid Micelle-Induced Oxidative Stress and Monolayer Permeability in Caco-2 Intestinal Epithelial Cells

In a Caco-2 cell model of dietary fat-induced intestinal epithelial cell cytotoxicity, oxidative stress and barrier impairment, researchers investigated the relative protection afforded by an anthocyanin-rich bilberry extract or resveratrol.
[Food & Function]
Ershad, M., Shigenaga, M. K., & Bandy, B. (2021). Differential protection by anthocyanin-rich bilberry extract and resveratrol against lipid micelle-induced oxidative stress and monolayer permeability in Caco-2 intestinal epithelial cells. Food & Function. https://doi.org/10.1039/D0FO02377A Cite
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Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer

Combined bulk transcriptomic and single-cell RNA-sequencing analysis revealed decreased gene expression of markers for differentiated cells in patient-derived organoids derived from metastatic lesions.
[Stem Cell Reports]
Okamoto, T., duVerle, D., Yaginuma, K., Natsume, Y., Yamanaka, H., Kusama, D., Fukuda, M., Yamamoto, M., Perraudeau, F., Srivastava, U., Kashima, Y., Suzuki, A., Kuze, Y., Takahashi, Y., Ueno, M., Sakai, Y., Noda, T., Tsuda, K., Suzuki, Y., … Yao, R. (2021). Comparative Analysis of Patient-Matched PDOs Revealed a Reduction in OLFM4-Associated Clusters in Metastatic Lesions in Colorectal Cancer. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.02.012 Cite
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