Scientists found that deletion of Erk1/2 in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation and migration, expansion of intestinal stem cells and formation of polyp-like structures, leading to postnatal death.
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ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/early/2020/07/30/dev.185678 Cite
In the wound healing assay, berberine exhibited the ability to promote cell migration, indicating that berberine could probably recover the function of intestinal epithelial cells when the intestinal epithelial barrier was damaged by the peritoneal dialysis fluid.
[Journal of Ethnopharmacology]
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Zhang, D., Jiang, L., Wang, M., Jin, M., Zhang, X., Liu, D., Wang, Z., Yang, L., & Xu, X. (2020). Berberine inhibits intestinal epithelial barrier dysfunction in colon caused by peritoneal dialysis fluid by improving cell migration. Journal of Ethnopharmacology, 113206. https://doi.org/10.1016/j.jep.2020.113206 Cite
The authors demonstrate that the DNA damage-resistant Msi1+ cells are cycling intestinal stem cells that maintain and regenerate the intestinal epithelium.
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Intestinal exposure to inositol trisphosphate and phytate ingestion both promoted recovery following intestinal damage. Remarkably, inositol trisphosphate also induced growth of patient-derived intestinal organoids, stimulated HDAC3-dependent proliferation, and countered butyrate inhibition of colonic growth.
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Leukemia inhibitory factor (LIF) is a cytokine essential for maintaining pluripotency of mouse ESCs. Scientists found that LIF was present in the intestinal stem cell (ISC) niche in crypts and critical for the function of ISCs in maintaining the intestinal epithelial homeostasis and regeneration.
[Cell Death & Disease]
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Neuregulin 1 robustly stimulated proliferation in crypts and induced budding in organoids, in part through elevated and sustained activation of mitogen-activated protein kinase and AKT.
[Cell Stem Cell]
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Researchers used genetic and pharmacological inhibition of N-myristoyltransferase-1 (NMT1) to further dissect the role of this enzyme in cancer, and found an unexpected essential role for NMT1 at promoting lysosomal metabolic functions.