vascular endothelial cells

[Cell Biology International] Cardiac function, myocardial infarction area, apoptosis, and angiogenesis were all evaluated in a CHF rat model following treatment with human umbilical cord MSC-derived exosomes.

[Anti-Cancer Agents in Medicinal Chemistry] The authors identified five candidate genes, including ESM1，CXCR4，JAG1，FLT1 and PTK2 and two pathways, including Rap1 signaling pathway and PI3K-Akt signaling pathway in vascular endothelial cells that differentiate into tip cells and stalk cells using bioinformatic analysis.

[Experimental & Molecular Medicine] Scientists highlight the distinct contributions of IL-6 signaling to the pathogenesis of several types of cytokine storms and discuss potential therapeutic strategies for the management of cytokine storms, including those associated with sepsis and COVID-19.

[Journal of Cell Science] Human umbilical vein endothelial cells (HUVECs) elongated, activated TAGLN promoter and increased TAGLN transcripts in angiogenesis model. Genetic disruption of TAGLN augmented angiogenic behaviors of HUVECs, as did the disruption of TAGLN2 and TAGLN3 genes.

[Journal of Translational Medicine] Downregulation of miR-15b-5p under HG conditions promoted proliferation, migration, and tube formation of human retinal vascular endothelial cells.

[Frontiers in Cell and Developmental Biology] Scientists discuss various subpopulations of endothelial cells in the mammalian heart, which spatiotemporally regulate critical cellular and molecular processes of heart development via unique sets of angiocrine signaling pathways.