Regulation of Cardiomyocyte Fate Plasticity: A Key Strategy for Cardiac Regeneration

By
Justin.choi
-
0
28
Scientists summarize the latest research progress in cardiac regeneration and heart repair through altering cardiomyocyte fate plasticity, which is emerging as an effective strategy to compensate for the loss of functional cardiomyocytes and improve the impaired heart functions.
[Signal Transduction and Targeted Therapy]
1254621 {1254621:X99ZRVQU} 1 apa 50 default 1 158407 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22X99ZRVQU%22%2C%22library%22%3A%7B%22id%22%3A1254621%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gong%20et%20al.%22%2C%22parsedDate%22%3A%222021-01-27%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BGong%2C%20R.%2C%20Jiang%2C%20Z.%2C%20Zagidullin%2C%20N.%2C%20Liu%2C%20T.%2C%20%26amp%3B%20Cai%2C%20B.%20%282021%29.%20Regulation%20of%20cardiomyocyte%20fate%20plasticity%3A%20a%20key%20strategy%20for%20cardiac%20regeneration.%20%26lt%3Bi%26gt%3BSignal%20Transduction%20and%20Targeted%20Therapy%26lt%3B%5C%2Fi%26gt%3B%2C%20%26lt%3Bi%26gt%3B6%26lt%3B%5C%2Fi%26gt%3B%281%29%2C%201%26%23x2013%3B11.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41392-020-00413-2%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41392-020-00413-2%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3Ba%20title%3D%26%23039%3BCite%20in%20RIS%20Format%26%23039%3B%20class%3D%26%23039%3Bzp-CiteRIS%26%23039%3B%20data-zp-cite%3D%26%23039%3Bapi_user_id%3D1254621%26amp%3Bitem_key%3DX99ZRVQU%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BCite%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Regulation%20of%20cardiomyocyte%20fate%20plasticity%3A%20a%20key%20strategy%20for%20cardiac%20regeneration%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Rui%22%2C%22lastName%22%3A%22Gong%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zuke%22%2C%22lastName%22%3A%22Jiang%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naufal%22%2C%22lastName%22%3A%22Zagidullin%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tianyi%22%2C%22lastName%22%3A%22Liu%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Benzhi%22%2C%22lastName%22%3A%22Cai%22%7D%5D%2C%22abstractNote%22%3A%22With%20the%20high%20morbidity%20and%20mortality%20rates%2C%20cardiovascular%20diseases%20have%20become%20one%20of%20the%20most%20concerning%20diseases%20worldwide.%20The%20heart%20of%20adult%20mammals%20can%20hardly%20regenerate%20naturally%20after%20injury%20because%20adult%20cardiomyocytes%20have%20already%20exited%20the%20cell%20cycle%2C%20which%20subseqently%20triggers%20cardiac%20remodeling%20and%20heart%20failure.%20Although%20a%20series%20of%20pharmacological%20treatments%20and%20surgical%20methods%20have%20been%20utilized%20to%20improve%20heart%20functions%2C%20they%20cannot%20replenish%20the%20massive%20loss%20of%20beating%20cardiomyocytes%20after%20injury.%20Here%2C%20we%20summarize%20the%20latest%20research%20progress%20in%20cardiac%20regeneration%20and%20heart%20repair%20through%20altering%20cardiomyocyte%20fate%20plasticity%2C%20which%20is%20emerging%20as%20an%20effective%20strategy%20to%20compensate%20for%20the%20loss%20of%20functional%20cardiomyocytes%20and%20improve%20the%20impaired%20heart%20functions.%20First%2C%20residual%20cardiomyocytes%20in%20damaged%20hearts%20re-enter%20the%20cell%20cycle%20to%20acquire%20the%20proliferative%20capacity%20by%20the%20modifications%20of%20cell%20cycle-related%20genes%20or%20regulation%20of%20growth-related%20signals.%20Additionally%2C%20non-cardiomyocytes%20such%20as%20cardiac%20fibroblasts%2C%20were%20shown%20to%20be%20reprogrammed%20into%20cardiomyocytes%20and%20thus%20favor%20the%20repair%20of%20damaged%20hearts.%20Moreover%2C%20pluripotent%20stem%20cells%20have%20been%20shown%20to%20transform%20into%20cardiomyocytes%20to%20promote%20heart%20healing%20after%20myocardial%20infarction%20%28MI%29.%20Furthermore%2C%20in%20vitro%20and%20in%20vivo%20studies%20demonstrated%20that%20environmental%20oxygen%2C%20energy%20metabolism%2C%20extracellular%20factors%2C%20nerves%2C%20non-coding%20RNAs%2C%20etc.%20play%20the%20key%20regulatory%20functions%20in%20cardiac%20regeneration.%20These%20findings%20provide%20the%20theoretical%20basis%20of%20targeting%20cellular%20fate%20plasticity%20to%20induce%20cardiomyocyte%20proliferation%20or%20formation%2C%20and%20also%20provide%20the%20clues%20for%20stimulating%20heart%20repair%20after%20injury.%22%2C%22date%22%3A%222021-01-27%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41392-020-00413-2%22%2C%22ISSN%22%3A%222059-3635%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41392-020-00413-2%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-01-27T19%3A17%3A35Z%22%7D%7D%5D%7D
Gong, R., Jiang, Z., Zagidullin, N., Liu, T., & Cai, B. (2021). Regulation of cardiomyocyte fate plasticity: a key strategy for cardiac regeneration. Signal Transduction and Targeted Therapy, 6(1), 1–11. https://doi.org/10.1038/s41392-020-00413-2 Cite
Full Article