Aberrant CREB1 Activation in Prostate Cancer Disrupts Normal Prostate Luminal Cell Differentiation

By
Justin.choi
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0
34
Researchers discovered that CREB1 played a central role in maintaining new luminal cell survival and that oncogenesis dramatically changed the CREB1-induced transcriptome. CREB1 was active in luminal cells, but not basal cells.
[Oncogene]
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Watson, M. J., Berger, P. L., Banerjee, K., Frank, S. B., Tang, L., Ganguly, S. S., Hostetter, G., Winn, M., & Miranti, C. K. (2021). Aberrant CREB1 activation in prostate cancer disrupts normal prostate luminal cell differentiation. Oncogene, 1–13. https://doi.org/10.1038/s41388-021-01772-y Cite
Abstract