Uncategorized

[Montefiore Einstein] Ulrich Steidl, MD, PhD, Director, at Montefiore Einstein Comprehensive Cancer Center has been awared the International Society for Experimental Hematology (ISEH) 2025 McCulloch & Till Award.

[Cell Research] Researchers showed that Piezo1 is highly expressed in HSCs. Both genetic deletion and prolonged chemical activation of Piezo1 impair cultured HSC function, indicating that transient mechanical activation of Piezo1 is required for maintenance of HSCs in culture.

[Blood] Through a clustered regularly interspaced short palindromic repeats/Cas9 screen with a BCL11A–enhanced green fluorescent protein reporter, scientists identified the epigenetic reader SP140 as a suppressor of hematopoiesis.

[Nature Communications] Investigators showed that multiple stress responses converge on the RIPK3-MLKL axis to induce age-related changes in HSCs.

[Communications Biology] While therapeutic targeting of RAN has been difficult due to its structural features, through molecular dynamics simulations and docking studies, researchers have identified MAR-3.6.2 as a novel allosteric inhibitor that binds in a cryptic pocket in the C-terminal domain of RAN.

[Nature Communications] Investigators provided the therapeutic and resistant mechanisms of QUIZartinib and Omacetaxine Mepesuccinate and paved the way for targeted interventions in this acute myeloid leukemia (AML) subtype.

[Blood Advances] Scientists showed that allogeneic hematopoietic stem cell transplant is a viable curative strategy for ERCC6L2 disease when performed before transformation to an aggressive malignancy, for example myelodysplasia with excess blasts or acute myeloid leukemia.

[Haematologica] The authors synthesize concepts derived from recent advances in single-cell and multi-omics analyses, which have revealed profound heterogeneity among leukemic stem cells.

[Experimental Hematology & Oncology] Transcriptomic profiling was performed on MSCs from responder and non-responder patients to identify pathways differentially regulated according to clinical response. Among the pathways differentially regulated in MSCs according to treatment response, MAVS was identified as a relevant modulator, showing lower expression in Celyvir products from responder patients.

[Journal of Translational Medicine] The authors explore the impact of hypoxic preconditioning on umbilical cord derived-MSCs, with a particular focus on how reduced oxygen levels influence their biological traits and enhance their therapeutic potential.

[International Journal of Oral Science] To integrate insights into the development of teeth and periodontal tissues, this review synthesizes current knowledge on both developmental heterogeneity and subpopulation heterogeneity within neural crest-derived dental MSCs and related cells.

[PLoS Biology] Researchers showed Phosphorylated CTD Interacting Factor 1 (PCIF1), the N6,2′-O-dimethyladenosine (m6Am) methyltransferase, is essential for maintaining bone mass and promoting osteogenic differentiation of MSCs.