Role of PDE10A in Vascular Smooth Muscle Cell Hyperplasia and Pathological Vascular Remodeling

Intimal hyperplasia is a common feature of vascular remodeling disorders. Accumulation of synthetic smooth muscle cell (SMC)-like cells is the main underlying cause. Researchers investigated the function of PDE10A in smooth muscle cell proliferation and intimal hyperplasia both in vitro and in vivo.