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[Foundation Medicine, Inc.] Foundation Medicine, Inc., announced that it has received approval from the US FDA for FoundationOne^®CDx to be used as a companion diagnostic (CDx) for TEPMETKO^® (tepotinib) developed by EMD Serono, the healthcare business of Merck KGaA, Darmstadt, Germany in the US and Canada.

[Nature Communications] Lineage tracing of alveolar fibroblasts was carried out during fibrosis development and delayed resolution in aged mice. Histological analyses, single-cell transcriptomics, and ex vivo models including alveolar organoids and precision-cut lung slice cultures were employed.

[Journal of Medicinal Chemistry] Researchers develop a lung-restricted ALK5 inhibitor that shows strong antifibrotic activity in preclinical models, highlighting a targeted inhalation strategy for idiopathic pulmonary fibrosis.

[Scientific Reports] Investigators reported the first intracellular proteomic analysis of cigarette smoke exposure in fully differentiated primary human bronchial epithelial cells

[Scientific Reports] Scientists investigated the protective effect of cilostazol against amiodarone-induced pulmonary fibrosis and to elucidate its underlying mechanisms.

[NPJ Precision Oncology] Researchers employed single-nucleus RNA sequencing on 44 pulmonary nodule and paired normal specimens to investigate the cellular mechanisms governing the change from pulmonary nodules to early-stage lung adenocarcinoma at single-cell resolution.

[NPJ Precision Oncology] The authors showed that a specific steroid-regulating enzyme, HSD11B1, acts as a protective factor against lung cancer in people who have never smoked.

[Journal of Translational Medicine] Investigators elucidated the role and underlying mechanism by which β-catenin lactylation regulates ferroptosis to drive NSCLC progression

[Oncogenesis] Scientists summarise current knowledge of mesothelioma metabolism, highlighting how recurrent genetic alterations including CDKN2A, MTAP, BAP1, NF2 and TP53 influence metabolic phenotypes.

[Nature Immunology] Researchers discuss the evolving spectrum of M. tuberculosis infection outcomes and Tuberculosis disease, how the host immune response determines and unfolds across this spectrum, and how the natural diversity of M. tuberculosis contributes to this complexity.

[Journal of Translational Medicine] The authors highlight the roles of various immune cells in viral pneumonia and explores the mechanisms by which viral infections induce immune cell abnormalities, offering insights for future clinical strategies and improving prognosis for respiratory viral infections.

[Nature Reviews Microbiology] Historically, the phage life cycle was viewed primarily through the lens of how excision, replication, and packaging drive the formation of infective particles. Scientists re-examine the temperate phage life cycle in light of emerging insights that expand on this framework with unanticipated complexities.