Uncategorized

[Nature] Scientists demonstrated across multiple scales that inhibition of matrix mechanosensing in persistently activated cardiac fibroblasts potentiates—in concert with soluble regulators of the TGFβ pathway—a robust transcriptomic, morphological, and metabolic shift towards quiescence.

[Science Advances] Investigators three-dimensionally bioprinted ECM and cells into collagen-based high-resolution internally perfusable scaffolds that integrate with a vascular and perfusion organ-on-a-chip reactor to form a complete tissue engineering platform.

[FluidForm Bio] FluidForm Bio^™ announced that the United States Patent and Trademark Office has issued a new patent which expands the foundational intellectual property exclusively licensed to the company from Carnegie Mellon University around Freeform Reversible Embedding of Suspended Hydrogels (FRESH^™).

[Journal of Clinical Investigation] Researchers identified a conspicuous dysregulation of the TGF-β pathway early in the disease process and proposed that the collagen VI–deficient matrix is not capable of regulating the dynamic TGF-β bioavailability both at baseline and in response to muscle injury.

[Nature Communications] Fibroblasts on viscoelastic substrates display larger nuclei, lower chromatin compaction, and differential expression of distinct sets of genes related to the cytoskeleton and nuclear function, compared to those on elastic surfaces.

[FesariusTherapeutics, Inc. ] FesariusTherapeutics, Inc. announced it has entered into an exclusive, multi-year manufacturing and supply agreement with Regenity Biosciences. The agreement provides Regenity exclusive manufacturing responsibility for DermiSphere hDRT, an new class of collagen-based dermal regeneration templates.

[Scientific Reports] Scientists identified the optimal wavelength and irradiation fluence for promoting the proliferation of human umbilical cord MSCs by comparing the effects of different wavelengths and irradiation fluences.

[Cell Death & Disease] Investigators showed that glioma-associated MSCs are able to spontaneously fuse with glioma cells both in vitro and in vivo.