[Cancer Immunology Research] Researchers described the characterization of MiNK-215, an allogeneic human invariant NK T (iNKT) cell therapy in which iNKT cells were engineered to express an fibroblast activation protein (FAP)-targeting CAR and to secrete IL15 to remodel the tumor microenvironment and enhance antitumor activity.

[Cancer Immunology Research] Scientists investigated a universal strategy for boosting transferred tumor-specific T cells for which boosting is provided through a CAR that is paired with a vaccine encoding the CAR target antigen.

[Cancer Immunology Research] Investigators showed that allogeneic human CD4+ invariant NK T cells formed stably adhered bi-cellular complexes with monocyte-derived dendritic cells (DC) that migrated together as pairs and showed extended DC calcium signaling.

[Tr1X (Businesswire)] Tr1X announced the first clinical data from its ongoing Phase I study of TRX103 in patients with hematologic malignancies undergoing HLA-mismatched hematopoietic peripheral stem cell transplantation.

[Science Translational Medicine] Researchers developed CAR T cells targeting the B cell receptor carrying IGHV4-34 (CART4-34). They found that CART4-34 showed specific cytotoxicity and cytokine secretion toward IGHV4-34+ malignant B cells.

[Nature Communications] In models of acute myeloid leukemia, scientists showed that a CD38-targeting synapse-stabilizing receptor boosts cytolysis of antigen-low cancer cells via a C-type lectin-like molecule-1 (CLL1)-specific CAR and a survivin-specific T cell receptor.

[Cell Death Discovery] The authors explore the multifaceted roles of SUMOylation in Treg cell biology, emphasizing its influence on differentiation, maturation, transcriptional and epigenetic regulation, and metabolic reprogramming.

[Journal of Advanced Research] Investigators presented the identification of two common and independently acting pathways induced by AR-antagonists and supraphysiological androgen levels, used in bipolar androgen therapy, to mediate growth inhibition and induction of cellular senescence in CRPC.

[Oncogene] The authors designed and developed a series of VHL-based proteolysis-targeting chimera (PROTAC) degraders of EZH2 using EPZ-6438 as a ligand and identified PROTAC-6272 as a lead compound.

[EMBO Molecular Medicine] Researchers revealed that the castration tolerance of LSCmed progenitor cells, the mouse equivalent of human prostatic Club cells, arises not from intrinsic properties, but from significant transcriptional reprogramming.

[Journal for Immunotherapy of Cancer] Scientists evaluated the antitumor effects of the oncolytic virus oncolytic herpes simplex virus type 2 (OH2) in prostate cancer cell lines and mouse models.

[Signal Transduction and Targeted Therapy] Researchers found that SARS-CoV-2 infection boosts CD147 inducible up-regulation in the lung tissues of virus-infected rhesus macaques coupled with down-regulated membrane-bound ACE2, which conduces to extended virus infection and severe pathological lesions.