Researchers analyzed the collagen and matrix metalloproteinase 1 (MMP1) expression in Neurofibromatosis 1 cutaneous neurofibroma and found excessive expression of collagen and reduced expression of MMP1.
[Cell Death & Disease]
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Tsuji, G., Takai-Yumine, A., Kato, T., & Furue, M. (2021). Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine. Cell Death & Disease, 12(6), 1–11. https://doi.org/10.1038/s41419-021-03802-9 Cite