SARS-CoV-2 Variants, Spike Mutations and Immune Escape

0
33
The authors summarize the literature on mutations of the SARS-CoV-2 spike protein, the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the protein structure, and discuss them in the context of observed mutation frequencies in global sequence datasets.
[Nature Reviews Microbiology]
6445218 {6445218:7DFDDHMB} 1 apa 50 default 1 162861 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3Afalse%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%227DFDDHMB%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Harvey%20et%20al.%22%2C%22parsedDate%22%3A%222021-06-01%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%26lt%3Bdiv%20class%3D%26quot%3Bcsl-bib-body%26quot%3B%20style%3D%26quot%3Bline-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%26quot%3B%26gt%3B%5Cn%20%20%26lt%3Bdiv%20class%3D%26quot%3Bcsl-entry%26quot%3B%26gt%3BHarvey%2C%20W.%20T.%2C%20Carabelli%2C%20A.%20M.%2C%20Jackson%2C%20B.%2C%20Gupta%2C%20R.%20K.%2C%20Thomson%2C%20E.%20C.%2C%20Harrison%2C%20E.%20M.%2C%20Ludden%2C%20C.%2C%20Reeve%2C%20R.%2C%20Rambaut%2C%20A.%2C%20Peacock%2C%20S.%20J.%2C%20%26amp%3B%20Robertson%2C%20D.%20L.%20%282021%29.%20SARS-CoV-2%20variants%2C%20spike%20mutations%20and%20immune%20escape.%20%26lt%3Bi%26gt%3BNature%20Reviews%20Microbiology%26lt%3B%5C%2Fi%26gt%3B%2C%201%26%23x2013%3B16.%20%26lt%3Ba%20class%3D%26%23039%3Bzp-DOIURL%26%23039%3B%20href%3D%26%23039%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41579-021-00573-0%26%23039%3B%26gt%3Bhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41579-021-00573-0%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3Ba%20title%3D%26%23039%3BCite%20in%20RIS%20Format%26%23039%3B%20class%3D%26%23039%3Bzp-CiteRIS%26%23039%3B%20data-zp-cite%3D%26%23039%3Bapi_user_id%3D6445218%26amp%3Bitem_key%3D7DFDDHMB%26%23039%3B%20href%3D%26%23039%3Bjavascript%3Avoid%280%29%3B%26%23039%3B%26gt%3BCite%26lt%3B%5C%2Fa%26gt%3B%20%26lt%3B%5C%2Fdiv%26gt%3B%5Cn%26lt%3B%5C%2Fdiv%26gt%3B%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22SARS-CoV-2%20variants%2C%20spike%20mutations%20and%20immune%20escape%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22William%20T.%22%2C%22lastName%22%3A%22Harvey%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alessandro%20M.%22%2C%22lastName%22%3A%22Carabelli%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ben%22%2C%22lastName%22%3A%22Jackson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ravindra%20K.%22%2C%22lastName%22%3A%22Gupta%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Emma%20C.%22%2C%22lastName%22%3A%22Thomson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ewan%20M.%22%2C%22lastName%22%3A%22Harrison%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Catherine%22%2C%22lastName%22%3A%22Ludden%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Richard%22%2C%22lastName%22%3A%22Reeve%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andrew%22%2C%22lastName%22%3A%22Rambaut%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sharon%20J.%22%2C%22lastName%22%3A%22Peacock%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22David%20L.%22%2C%22lastName%22%3A%22Robertson%22%7D%5D%2C%22abstractNote%22%3A%22%5Cu416c%5Cu7468%5Cu6f75%5Cu6768%5Cu206d%5Cu6f73%5Cu7420%5Cu6d75%5Cu7461%5Cu7469%5Cu6f6e%5Cu7320%5Cu696e%5Cu2074%5Cu6865%5Cu2073%5Cu6576%5Cu6572%5Cu6520%5Cu6163%5Cu7574%5Cu6520%5Cu7265%5Cu7370%5Cu6972%5Cu6174%5Cu6f72%5Cu7920%5Cu7379%5Cu6e64%5Cu726f%5Cu6d65%5Cu2063%5Cu6f72%5Cu6f6e%5Cu6176%5Cu6972%5Cu7573%5Cu2032%5Cu2028%5Cu5341%5Cu5253%5Cu2d43%5Cu6f56%5Cu2d32%5Cu2920%5Cu6765%5Cu6e6f%5Cu6d65%5Cu2061%5Cu7265%5Cu2065%5Cu7870%5Cu6563%5Cu7465%5Cu6420%5Cu746f%5Cu2062%5Cu6520%5Cu6569%5Cu7468%5Cu6572%5Cu2064%5Cu656c%5Cu6574%5Cu6572%5Cu696f%5Cu7573%5Cu2061%5Cu6e64%5Cu2073%5Cu7769%5Cu6674%5Cu6c79%5Cu2070%5Cu7572%5Cu6765%5Cu6420%5Cu6f72%5Cu2072%5Cu656c%5Cu6174%5Cu6976%5Cu656c%5Cu7920%5Cu6e65%5Cu7574%5Cu7261%5Cu6c2c%5Cu2061%5Cu2073%5Cu6d61%5Cu6c6c%5Cu2070%5Cu726f%5Cu706f%5Cu7274%5Cu696f%5Cu6e20%5Cu7769%5Cu6c6c%5Cu2061%5Cu6666%5Cu6563%5Cu7420%5Cu6675%5Cu6e63%5Cu7469%5Cu6f6e%5Cu616c%5Cu2070%5Cu726f%5Cu7065%5Cu7274%5Cu6965%5Cu7320%5Cu616e%5Cu6420%5Cu6d61%5Cu7920%5Cu616c%5Cu7465%5Cu7220%5Cu696e%5Cu6665%5Cu6374%5Cu6976%5Cu6974%5Cu792c%5Cu2064%5Cu6973%5Cu6561%5Cu7365%5Cu2073%5Cu6576%5Cu6572%5Cu6974%5Cu7920%5Cu6f72%5Cu2069%5Cu6e74%5Cu6572%5Cu6163%5Cu7469%5Cu6f6e%5Cu7320%5Cu7769%5Cu7468%5Cu2068%5Cu6f73%5Cu7420%5Cu696d%5Cu6d75%5Cu6e69%5Cu7479%5Cu2e20%5Cu5468%5Cu6520%5Cu656d%5Cu6572%5Cu6765%5Cu6e63%5Cu6520%5Cu6f66%5Cu2053%5Cu4152%5Cu532d%5Cu436f%5Cu562d%5Cu3220%5Cu696e%5Cu206c%5Cu6174%5Cu6520%5Cu3230%5Cu3139%5Cu2077%5Cu6173%5Cu2066%5Cu6f6c%5Cu6c6f%5Cu7765%5Cu6420%5Cu6279%5Cu2061%5Cu2070%5Cu6572%5Cu696f%5Cu6420%5Cu6f66%5Cu2072%5Cu656c%5Cu6174%5Cu6976%5Cu6520%5Cu6576%5Cu6f6c%5Cu7574%5Cu696f%5Cu6e61%5Cu7279%5Cu2073%5Cu7461%5Cu7369%5Cu7320%5Cu6c61%5Cu7374%5Cu696e%5Cu6720%5Cu6162%5Cu6f75%5Cu7420%5Cu3131%5Cu206d%5Cu6f6e%5Cu7468%5Cu732e%5Cu2053%5Cu696e%5Cu6365%5Cu206c%5Cu6174%5Cu6520%5Cu3230%5Cu3230%5Cu2c20%5Cu686f%5Cu7765%5Cu7665%5Cu722c%5Cu2053%5Cu4152%5Cu532d%5Cu436f%5Cu562d%5Cu3220%5Cu6576%5Cu6f6c%5Cu7574%5Cu696f%5Cu6e20%5Cu6861%5Cu7320%5Cu6265%5Cu656e%5Cu2063%5Cu6861%5Cu7261%5Cu6374%5Cu6572%5Cu697a%5Cu6564%5Cu2062%5Cu7920%5Cu7468%5Cu6520%5Cu656d%5Cu6572%5Cu6765%5Cu6e63%5Cu6520%5Cu6f66%5Cu2073%5Cu6574%5Cu7320%5Cu6f66%5Cu206d%5Cu7574%5Cu6174%5Cu696f%5Cu6e73%5Cu2c20%5Cu696e%5Cu2074%5Cu6865%5Cu2063%5Cu6f6e%5Cu7465%5Cu7874%5Cu206f%5Cu6620%5Cue280%5Cu9876%5Cu6172%5Cu6961%5Cu6e74%5Cu7320%5Cu6f66%5Cu2063%5Cu6f6e%5Cu6365%5Cu726e%5Cue280%5Cu992c%5Cu2074%5Cu6861%5Cu7420%5Cu696d%5Cu7061%5Cu6374%5Cu2076%5Cu6972%5Cu7573%5Cu2063%5Cu6861%5Cu7261%5Cu6374%5Cu6572%5Cu6973%5Cu7469%5Cu6373%5Cu2c20%5Cu696e%5Cu636c%5Cu7564%5Cu696e%5Cu6720%5Cu7472%5Cu616e%5Cu736d%5Cu6973%5Cu7369%5Cu6269%5Cu6c69%5Cu7479%5Cu2061%5Cu6e64%5Cu2061%5Cu6e74%5Cu6967%5Cu656e%5Cu6963%5Cu6974%5Cu792c%5Cu2070%5Cu726f%5Cu6261%5Cu626c%5Cu7920%5Cu696e%5Cu2072%5Cu6573%5Cu706f%5Cu6e73%5Cu6520%5Cu746f%5Cu2074%5Cu6865%5Cu2063%5Cu6861%5Cu6e67%5Cu696e%5Cu6720%5Cu696d%5Cu6d75%5Cu6e65%5Cu2070%5Cu726f%5Cu6669%5Cu6c65%5Cu206f%5Cu6620%5Cu7468%5Cu6520%5Cu6875%5Cu6d61%5Cu6e20%5Cu706f%5Cu7075%5Cu6c61%5Cu7469%5Cu6f6e%5Cu2e20%5Cu5468%5Cu6572%5Cu6520%5Cu6973%5Cu2065%5Cu6d65%5Cu7267%5Cu696e%5Cu6720%5Cu6576%5Cu6964%5Cu656e%5Cu6365%5Cu206f%5Cu6620%5Cu7265%5Cu6475%5Cu6365%5Cu6420%5Cu6e65%5Cu7574%5Cu7261%5Cu6c69%5Cu7a61%5Cu7469%5Cu6f6e%5Cu206f%5Cu6620%5Cu736f%5Cu6d65%5Cu2053%5Cu4152%5Cu532d%5Cu436f%5Cu562d%5Cu3220%5Cu7661%5Cu7269%5Cu616e%5Cu7473%5Cu2062%5Cu7920%5Cu706f%5Cu7374%5Cu7661%5Cu6363%5Cu696e%5Cu6174%5Cu696f%5Cu6e20%5Cu7365%5Cu7275%5Cu6d3b%5Cu2068%5Cu6f77%5Cu6576%5Cu6572%5Cu2c20%5Cu6120%5Cu6772%5Cu6561%5Cu7465%5Cu7220%5Cu756e%5Cu6465%5Cu7273%5Cu7461%5Cu6e64%5Cu696e%5Cu6720%5Cu6f66%5Cu2063%5Cu6f72%5Cu7265%5Cu6c61%5Cu7465%5Cu7320%5Cu6f66%5Cu2070%5Cu726f%5Cu7465%5Cu6374%5Cu696f%5Cu6e20%5Cu6973%5Cu2072%5Cu6571%5Cu7569%5Cu7265%5Cu6420%5Cu746f%5Cu2065%5Cu7661%5Cu6c75%5Cu6174%5Cu6520%5Cu686f%5Cu7720%5Cu7468%5Cu6973%5Cu206d%5Cu6179%5Cu2069%5Cu6d70%5Cu6163%5Cu7420%5Cu7661%5Cu6363%5Cu696e%5Cu6520%5Cu6566%5Cu6665%5Cu6374%5Cu6976%5Cu656e%5Cu6573%5Cu732e%5Cu204e%5Cu6f6e%5Cu6574%5Cu6865%5Cu6c65%5Cu7373%5Cu2c20%5Cu6d61%5Cu6e75%5Cu6661%5Cu6374%5Cu7572%5Cu6572%5Cu7320%5Cu6172%5Cu6520%5Cu7072%5Cu6570%5Cu6172%5Cu696e%5Cu6720%5Cu706c%5Cu6174%5Cu666f%5Cu726d%5Cu7320%5Cu666f%5Cu7220%5Cu6120%5Cu706f%5Cu7373%5Cu6962%5Cu6c65%5Cu2075%5Cu7064%5Cu6174%5Cu6520%5Cu6f66%5Cu2076%5Cu6163%5Cu6369%5Cu6e65%5Cu2073%5Cu6571%5Cu7565%5Cu6e63%5Cu6573%5Cu2c20%5Cu616e%5Cu6420%5Cu6974%5Cu2069%5Cu7320%5Cu6372%5Cu7563%5Cu6961%5Cu6c20%5Cu7468%5Cu6174%5Cu2073%5Cu7572%5Cu7665%5Cu696c%5Cu6c61%5Cu6e63%5Cu6520%5Cu6f66%5Cu2067%5Cu656e%5Cu6574%5Cu6963%5Cu2061%5Cu6e64%5Cu2061%5Cu6e74%5Cu6967%5Cu656e%5Cu6963%5Cu2063%5Cu6861%5Cu6e67%5Cu6573%5Cu2069%5Cu6e20%5Cu7468%5Cu6520%5Cu676c%5Cu6f62%5Cu616c%5Cu2076%5Cu6972%5Cu7573%5Cu2070%5Cu6f70%5Cu756c%5Cu6174%5Cu696f%5Cu6e20%5Cu6973%5Cu2064%5Cu6f6e%5Cu6520%5Cu616c%5Cu6f6e%5Cu6773%5Cu6964%5Cu6520%5Cu6578%5Cu7065%5Cu7269%5Cu6d65%5Cu6e74%5Cu7320%5Cu746f%5Cu2065%5Cu6c75%5Cu6369%5Cu6461%5Cu7465%5Cu2074%5Cu6865%5Cu2070%5Cu6865%5Cu6e6f%5Cu7479%5Cu7069%5Cu6320%5Cu696d%5Cu7061%5Cu6374%5Cu7320%5Cu6f66%5Cu206d%5Cu7574%5Cu6174%5Cu696f%5Cu6e73%5Cu2e20%5Cu496e%5Cu2074%5Cu6869%5Cu7320%5Cu5265%5Cu7669%5Cu6577%5Cu2c20%5Cu7765%5Cu2073%5Cu756d%5Cu6d61%5Cu7269%5Cu7a65%5Cu2074%5Cu6865%5Cu206c%5Cu6974%5Cu6572%5Cu6174%5Cu7572%5Cu6520%5Cu6f6e%5Cu206d%5Cu7574%5Cu6174%5Cu696f%5Cu6e73%5Cu206f%5Cu6620%5Cu7468%5Cu6520%5Cu5341%5Cu5253%5Cu2d43%5Cu6f56%5Cu2d32%5Cu2073%5Cu7069%5Cu6b65%5Cu2070%5Cu726f%5Cu7465%5Cu696e%5Cu2c20%5Cu7468%5Cu6520%5Cu7072%5Cu696d%5Cu6172%5Cu7920%5Cu616e%5Cu7469%5Cu6765%5Cu6e2c%5Cu2066%5Cu6f63%5Cu7573%5Cu696e%5Cu6720%5Cu6f6e%5Cu2074%5Cu6865%5Cu6972%5Cu2069%5Cu6d70%5Cu6163%5Cu7473%5Cu206f%5Cu6e20%5Cu616e%5Cu7469%5Cu6765%5Cu6e69%5Cu6369%5Cu7479%5Cu2061%5Cu6e64%5Cu2063%5Cu6f6e%5Cu7465%5Cu7874%5Cu7561%5Cu6c69%5Cu7a69%5Cu6e67%5Cu2074%5Cu6865%5Cu6d20%5Cu696e%5Cu2074%5Cu6865%5Cu2070%5Cu726f%5Cu7465%5Cu696e%5Cu2073%5Cu7472%5Cu7563%5Cu7475%5Cu7265%5Cu2c20%5Cu616e%5Cu6420%5Cu6469%5Cu7363%5Cu7573%5Cu7320%5Cu7468%5Cu656d%5Cu2069%5Cu6e20%5Cu7468%5Cu6520%5Cu636f%5Cu6e74%5Cu6578%5Cu7420%5Cu6f66%5Cu206f%5Cu6273%5Cu6572%5Cu7665%5Cu6420%5Cu6d75%5Cu7461%5Cu7469%5Cu6f6e%5Cu2066%5Cu7265%5Cu7175%5Cu656e%5Cu6369%5Cu6573%5Cu2069%5Cu6e20%5Cu676c%5Cu6f62%5Cu616c%5Cu2073%5Cu6571%5Cu7565%5Cu6e63%5Cu6520%5Cu6461%5Cu7461%5Cu7365%5Cu7473%3F%22%2C%22date%22%3A%222021-06-01%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41579-021-00573-0%22%2C%22ISSN%22%3A%221740-1534%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41579-021-00573-0%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-01T18%3A04%3A47Z%22%7D%7D%5D%7D
Harvey, W. T., Carabelli, A. M., Jackson, B., Gupta, R. K., Thomson, E. C., Harrison, E. M., Ludden, C., Reeve, R., Rambaut, A., Peacock, S. J., & Robertson, D. L. (2021). SARS-CoV-2 variants, spike mutations and immune escape. Nature Reviews Microbiology, 1–16. https://doi.org/10.1038/s41579-021-00573-0 Cite
Full Article