Defective Chromatin Architectures in Embryonic Stem Cells Derived from Somatic Cell Nuclear Transfer Impair Their Differentiation Potentials

Researchers employed ATAC-seq and Hi-C techniques to explore the chromatin accessibility and 3D genome organization of nuclear transfer ESCs (ntESCs) and showed that the chromatin accessibility and genome structures of somatic cells were re-arranged to ESC-like states overall in ntESCs.