ROS Activated Prodrug for ALDH Overexpressed Cancer Stem Cells

By
Justin.choi
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0
136
Researchers introduced a prodrug consisting of 1,3-oxathiolane as an ROS responsive scaffold, and an aldehyde protecting group of DEAB to deliver the co-treatment of anti-cancer drug and ALDH inhibitor upon reaction with ROS.
[Chemical Communications]

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AbstractGraphical Abstract