| Vol. 16.20 – 25 May, 2022 |
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| By performing fate mapping in primary human tissue, investigators demonstrated that astrocytes derived from the ventricular and outer subventricular zone niches populated anatomically distinct layers. [Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed the detection of cell surface death receptor target on CD146-enriched circulating tumor cells captured from the blood of mice bearing glioblastoma (GBM) and patients diagnosed with GBM. [Nature Communications] |
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| The authors used single-nucleus RNA sequencing to survey the gene expression profiles of rabies-infected neurons and assessed their correspondence with established transcriptomic cell types. [Proceedings of the National Academy of Sciences of the United States of America] |
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| An analysis included recovery of precursor-enriched transcriptional regulatory proteins not found to be differentially expressed in previous transcriptomic datasets. [Cell Reports] |
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| Researchers demonstrated that cyclic AMP (cAMP) triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells. [Cell Death & Disease] |
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| The authors found that circRNA derived from the pantothenate kinase 1 gene (circ-Pank1) could adsorb miR-7a-5p and upregulate the expression of α-synuclein (α-syn), which was a molecular hallmark closely related to Parkinson’s disease. [Cell Death & Disease] |
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| Investigators found that glycogen synthase kinase 3β (GSK3β) was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal. [Oncogenesis] |
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| Researchers compared the ring finger protein 216 (RNF216) expression in glioblastoma (GBM) tissues and normal peritumoral tissues and examined the effects of RNF216 overexpression/knockdown on tumorigenesis, radioresistance, and the p53 pathway in GBM. [Molecular Neurobiology] |
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| Scientists investigated if ferroptosis was involved in neurotoxicity post PM2.5 exposure and its underlying mechanism. [Environmental Toxicology] |
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| Researchers investigated the origins of glioblastoma (GBM), and it focused primarily on developmental gliogenic processes. [World Journal of Surgical Oncology] |
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| Investigators summarize the potential role of necroptosis in Alzheimer’s disease (AD) progression and the therapeutic capacity of targeting necroptosis for AD patients. [ACS Chemical Neuroscience] |
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| The authors review the current state of research in this promising field of Alzheimer’s disease therapy development. [Cellular and Molecular Neurobiology] |
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| PharmaJet® announced that its partner, the Institute for Molecular Medicine was awarded a $12 Million grant from the National Institute on Aging division of the National Institutes of Health. [PharmaJet®] |
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| The Davos Alzheimer’s Collaborative announced the recipients of a grant program aiming for the early detection of cognitive symptoms. The early detection grants total $4.5 Million from 8 countries across North America, Asia, and Africa. [Davos Alzheimer’s Collaborative] |
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| July 31 – August 5, 2022 Castelldefels, Spain |
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| Baylor College of Medicine – Houston, Texas, United States |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| McLean Hospital – Boston, Massachusetts, United States |
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| Max Planck Institute for Neurobiology of Behavior – Bonn, Germany |
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| Rush University – Chicago, Illinois, United States |
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