Vol. 9.16 – 5 May, 2023 TOP STORY BRCA2 Germline Mutations Identify Gastric Cancers Responsive to PARP Inhibitors To analyze the responsiveness of gastric cancer to PARP inhibitors, scientists exploited a gastroesophageal adenocarcinoma platform of patient-derived xenografts (PDX) and PDX-derived primary cells. [Cancer Research] Abstract PUBLICATIONSRanked by the impact factor of the journal Functional Characterization of Age-Dependent p16 Epimutation Reveals Biological Drivers and Therapeutic Targets for Colorectal Cancer Investigators established a mouse model that replicated two common genetic and epigenetic events observed in human colorectal cancers: Apc mutation and p16 epimutation. [Journal of Experimental & Clinical Cancer Research] Full Article UTP18-Mediated p21 mRNA Instability Drives Adenoma-Carcinoma Progression in Colorectal Cancer Researchers used in-depth quantitative proteomics combined with survival analysis, revealing that the ribosome protein U3 small nucleolar RNA-associated protein 18 homolog (UTP18) was consistently upregulated in the progression of colorectal adenoma to carcinoma. [Cell Reports] Full ArticleGraphical Abstract Peritoneal High-Fat Environment Promotes Peritoneal Metastasis of Gastric Cancer Cells through Activation of NSUN2-Mediated ORAI2 m5C Modification Transcriptome results suggested that NSUN2 expression was significantly upregulated in peritoneal metastasis (PM) and patients with high NSUN2 expression of PM predicted a worse prognosis. [Oncogene] Abstract Glutathione Peroxidase 2 Knockdown Suppresses Gastric Cancer Progression and Metastasis via Regulation of Kynurenine Metabolism The authors found that glutathione peroxidase-2 was overexpressed and negatively correlated with poor prognosis by using clinical gastric cancer samples for validation. [Oncogene] Full Article WIPI2 Enhances the Vulnerability of Colorectal Cancer Cells to Erastin via Bioinformatics Analysis and Experimental Verification Investigators analyzed the expression of WD Repeat Domain Phosphoinositide Interacting 2 (WIPI2) in colorectal cancer versus normal tissues through The Cancer Genome Atlas. [Frontiers in Oncology] Full Article Dihydroartemisinin Inhibited Stem Cell-Like Properties and Enhanced Oxaliplatin Sensitivity of Colorectal Cancer via AKT/mTOR Signaling Researchers found that dihydroartemisinin (DHA) inhibited cell viability in HCT116 and SW620 cells. Moreover, DHA decreased cell clonogenicity, and improved oxaliplatin sensitivity. [Drug Development Research] Abstract Anti-Proliferative Potential and Oxidative Reactivity of Thermo-Oxidative Degradation Products of Stigmasterol and Stigmasteryl Esters for Human Intestinal Cells Scientists analyzed the anti-proliferative potential and genotoxicity of thermo-oxidatively treated stigmasterol, stigmasteryl linoleate, and oleate. [Scientific Reports] Full Article Ginseng Mediates Its Anti-Cancer Activity by Inhibiting the Expression of DNMTs and Reactivating Methylation-Silenced Genes in Colorectal Cancer A series of cell culture studies were conducted, followed by their interrogation in patient-derived 3D organoid models to evaluate Ginseng’s anti-cancer activity in colorectal cancer. [Carcinogenesis] Abstract Natural Oncolysis of Enterovirus 71 in Antitumor Therapy of Colorectal Cancer Enterovirus 71 (EV71) was exploited to be a novel oncolytic virus in colorectal cancer. It was revealed that EV71 infection could selectively cause colorectal cancer cells cytotoxicity but not primary intestinal epithelial cells. [Advanced Biology] Abstract REVIEWS Young-Onset Colorectal Cancer To better understand the underlying mechanism and define relationships between environmental factors and young-onset-colorectal cancer development, long-term prospective studies are needed with lifestyle data collected from childhood. [Nature Reviews Disease Primers] Abstract Crosstalk between Colorectal Cancer Cells and Cancer-Associated Fibroblasts in the Tumor Microenvironment Mediated by Exosomal Noncoding RNAs The authors review the current status and progress of research on cancer-associated fibroblastss-derived exosomal non-coding RNAs in colorectal cancer. [Frontiers in Immunology] Abstract Insight into Immune Checkpoint Inhibitor Therapy for Colorectal Cancer from the Perspective of Circadian Clocks Scientists highlight the crosstalk between the tumor immune microenvironment in colorectal cancer (CRC) and the immunogenicity of CRC cells based on the circadian clocks. [Immunology] Full Article INDUSTRY AND POLICY NEWS $8.7M USD for World’s Largest Colorectal Cancer Registry The international registry of colorectal cancer patients and relatives, supporting earlier diagnosis and research to improve patient outcomes, has received $8.7 million USD from the US National Institutes of Health. [University of Melbourne] Press Release FEATURED EVENT The Resistant Tumor Microenvironment May 7 – 10, 2023 Vancouver, British Columbia, Canada > See All Events JOB OPPORTUNITIES Postdoctoral Positions – Celiac Disease California Institute of Technology – Pasadena, California, United States Postdoctoral Training Fellow – Colorectal Cancer The Francis Crick Institute – London, England, United Kingdom Postdoctoral Research Associate – Oncology St. Jude Children’s Research Hospital – Memphis, Tennessee, United States Senior Research Scientist – Rectal, Colon, and Anal Cancer Biology Memorial Sloan Kettering Cancer Center – New York City, New York, United States Research Technician – Health Science Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States > See All Jobs Brought to you by Science News Intestinal Cell News Archives Contact Us