[Blood] To model in vivo cancer stem cell/tumor microenvironment interactions and elucidate their functional consequences, scientists focused on myelofibrosis, a stem cell driven myeloproliferative neoplasm.

[Journal of Experimental Medicine] Researchers reported that shear stress triggers adaptation in mitochondrial composition, ultrastructure, and function, which are essential for hematopoietic fate and engraftment potential.

[Cell Reports] The authors reported that expression of the ribosomal protein RPL22 is frequently reduced in human myelodysplastic syndrome and AML, and reduced RPL22 expression is associated with worse outcomes.

[Cell Reports] Investigators identified age-associated changes in mouse thymic epithelial cells, mesenchyme, endothelium, and hematopoietic antigen-presenting cells from birth to one month of age using single-cell transcriptional profiling, flow cytometry, and imaging.

[Cell Death & Disease] Researchers demonstrated that Smad3 is significantly downregulated in myeloid-derived suppressor cell from colorectal cancer patients and tumor-bearing mouse models, impairing monocytic lineage maturation.

[Cell Death Discovery] Scientists demonstrated that prpf4 sequentially regulates erythrocyte proliferation and maturation during zebrafish definitive hematopoiesis.

[Scientific Reports] The authors investigated the contribution of circulating inflammatory mediators to the abnormalities in the megakaryocytic lineage characteristic of myelofibrosis and essential thrombocythemia.

[Lancet Haematology] In this single-arm, Phase II, multicenter trial, patients aged 15–70 years with relapsed or refractory T-cell acute lymphoblastic leukemia and an Eastern Cooperative Oncology Group performance status of 0–3 were eligible.

[Leukemia] Investigators introduced a construct with a RUNX1 frameshift mutation into B-cell lines with common HLA class I alleles and identified 13 neopeptides by immunopeptidomics.

[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists introduce hematologic organoids and how bone marrow, lymph nodes, thymus, and spleen organoids can replicate the hematologic malignancies for personalized therapies and research studies.

[Cell Reports Medicine] Researchers applied an integrated multi-omics approach together with functional experimental analyses to investigate metabolic adaptations that support mitochondrial quality control in TNBC.

[Cell Reports Medicine] Through imaging mass cytometry, researchers revealed that the CSF1R inhibitor PLX3397 indirectly activates cancer-associated fibroblasts, impedes T cell infiltration, and suppresses T cell function.