[Scientific Reports] Through in vitro experiments with human immortalized keratinocytes (HaCat), researchers found that atorvastatin calcium could significantly reduce the ultraviolet radiation B-induced increased expression of age-related protein p16 and age-related gene p21, and also reduce the up-regulation of inflammatory factors such as IL-1 and IL-6.

[Cellular & Molecular Immunology] Investigators found that the level of peroxisome proliferator-activated receptor gamma was substantially reduced in the skin lesions of patients, and replicating this reduction in mice led to rapid disease onset with multiple hallmarks of systemic lupus erythematosus.

[Cell Death & Differentiation] Scientists identified that ubiquitin-specific protease 19 (USP19) was downregulated in pancreatic tumor tissues and forced expression of USP19 diminished tumorigenicity of pancreatic cancer.

[Experimental & Molecular Medicine] The authors revealed that glutamyl-prolyl-tRNA synthetase 1 (EPRS1) expression levels were increased in the fibrotic kidneys of patients and mice, especially in fibroblasts and proximal tubular epithelial cells, on the basis of single-cell analysis and immunostaining of fibrotic kidneys.

[Stem Cell Research & Therapy] Researchers presented a novel approach to highly and efficiently generate mature megakaryocytes and functional platelets from human ESCs (hESCs). The in vivo functionality of hESC-derived platelets closely resembled that of natural human platelets.

[PLOS Biology] Researchers showed that ultraviolet and α-melanocyte-stimulating hormone triggered cilium formation in human melanocytes and melanoma cells.

[Nature Communications] Researchers generated Spint1-lacZ knock-in mice and observed Spint1 expression in embryonic pancreatic epithelium. Pancreas-specific Spint1 disruption significantly diminished islet size and mass, causing glucose intolerance and downregulation of MAF bZIP transcription factor A (MAFA) and insulin.

[Cellular & Molecular Biology Letters] Scientists found that sentrin/SUMO-specific protease 3 (SENP3) was highly expressed in prostate cancer (PCa) cell lines and tissues from PCa patients. Overexpressed SENP3 was associated with metastatic malignancy in PCa.

[iScience] Using DU145 and PC3 cell lines and a mouse xenograft model, scientists demonstrate that Trillin effectively inhibited CRPC cell viability, proliferation, migration, and invasion while promoting apoptosis and cell cycle arrest.

Researchers described novel trivalent antibodies, DNA-encoded tri-specific T cell engagers, targeting two glioblastoma multiforme antigens, epidermal growth factor receptor variant III (EGFRvIII) and IL-13Rα2,...

[Cancer Control] The authors summarize the clinical functions of ALDH1A1 as a novel regulator of chemoresistance, prognosis, and cancer stem cell development in pancreatic cancer.

[University of Illinois (UI) Health] A new therapy for brittle type 1 diabetes, the only treatment currently approved by the US FDA, is available exclusively at UI Health in Chicago.