[Cell] Investigators successfully generate primate organogenetic embryoids from cynomolgus totipotent blastomere-like stem cells (cTBLCs). cTBLCs, reprogrammed from PSCs and stably maintained, can display key totipotent-like molecular and functional features resembling zygotes/2–4-cell blastomeres.

[Nature Methods] Researchers showed that hiPSCs in defined cell culture geometries, two-dimensional colonies and three-dimensional lumenoids, enable multimodal measurements of epithelial-to-mesenchymal transition dynamics within a single experimental platform.

[Cell Stem Cell] Scientists demonstrated that human ventromedial hypothalamus and arcuate nucleus neurons can be generated from pluripotent stem cells by fine-tuned timing and duration of bone morphogenetic protein exposure.

[ACS Applied Materials & Interfaces] Researchers developed a laminin-511-inspired 3D zwitterionic hydrogel that supports long-term hPSC culture while maintaining pluripotency and differentiation potential.

[Stem Cell Reports] Using a defined protocol for the generation of iPSC-derived enteric neurons, scientists examined neuronal differentiation with immunohistochemistry, gene expression analysis, and cellular-resolution calcium imaging from day 21 to D57 of differentiation.

[Scientific Reports] Using the hiPSC lines iPS11 and iPS12 and thereof derived NPCs, the authors investigated whether genotoxic stress induced by low doses of benzo[a]pyrene diolepoxide or etoposide can similarly activate autophagy for cancer cell lines..

[Inflammation and Regeneration] The authors summarize current approaches for generating striatal cell types from PSCs, with a particular focus on medium spiny neurons, the principal projection neurons of the striatum.

[Heartseed Inc.] Heartseed announced the successful dosing of the first patient in its domestic Phase I/II EMERALD study of HS-005, allogeneic iPSC-derived cardiomyocyte spheroids administered via catheter, targeting severe heart failure caused by ischemic heart disease or dilated cardiomyopathy.

[CaixaResearch Institute] Dr. Gabriel Rabinovich has been awarded the 5th FERO Dr Baselga Grant. The project will focus on pancreatic ductal adenocarcinoma and explore how the tumor microenvironment interferes with the immune system’s ability to respond effectively.

[UNK News] University of Nebraska (UNK) at Kearney associate biology professor Dr. Joe Dolence has received a National Institutes of Health grant. The grant provides $500,000 to support research examining why males and females respond differently to peanut allergens and how those differences may influence the development of peanut allergies.

[Nature Immunology] Researchers used single-cell RNA sequencing to analyze regulatory T cells (Treg) in synovial tissues from patients with rhuematoid arthiriits. They identified two predominant Treg states, CD25hiCXCR6pos Treg cells and dysfunctional CD25loAREGpos Treg cells, both enriched in synovial tissues but not in blood.

[Cancer Gene Therapy] The authors explore how TFF3 signaling contributes to tumor progression and immune escape, and how its inhibition might reshape the tumor microenvironment (TME) to better support CAR-T cell activity