[USC Stem Cell] The California Institute for Regenerative Medicine (CIRM) has awarded the Keck School of Medicine of USC a $3.2 million, 5-year grant renewal in support of innovative undergraduate training in stem cell biology.

[The University of Utah] The University of Utah’s first Novel Alternative Methods (NAMs) Seed Grants were launched to accelerate development of human-relevant research models that can complement or, where appropriate, replace traditional animal models.

[Syntax Bio] Syntax Bio presented new research showing that its Cellgorithm^™ platform differentiated hiPSCs toward pancreatic beta cells in four days.

[Cell Stem Cell] The authors established epiblast complementation, a robust strategy for generating mice from donor PSCs.

[Cell Stem Cell] Investigators introduced a “subtractive multicellular engineering” approach to pluripotent stem cell-derived multicellular systems. This enhanced tissue maturity in human pluripotent stem cell-derived liver organoids.

[Nature Communications] Using a targeted CRISPRa screen, the authors identified Wt1 as a regulator of lineage-associated transcriptional programs during formative pluripotency.

[Cell Death & Disease] Scientists optimized motor neuron differentiation from hiPSCs to enhance synaptogenesis and enable high-resolution structural analysis using cryo-electron tomography.

[EMBO Reports] Investigators provided evidence that increased mitochondrial metabolism in Down syndrome stem cells reduces their ability to commit to neuroectoderm, one of the earliest steps in the development of the nervous system.

[Scientific Reports] Researchers compared the effects of bisphenol A and thalidomide on differentiation, gene expression, and enhancer-associated epigenetic states in hESCs and iPSCs.

[Molecular Reproduction and Development] The authors identified a positive functional relationship between protein arginine methyltransferase 7 (PRMT7) and ubiquitination of histone H2A at lysine 119 (H2AK119ub) in mESCs.

[Stem Cell Research] Scientists selected dermal fibroblasts from four early-onset sporadic Parkinson’s disease (PD) patients based on high PD polygenic risk scores and reprogrammed them into iPSCs using Sendai virus.

[Stem Cell Research] Dermal fibroblasts of a male dilated cardiomyopathy-patient carrying the truncating PRKAG2 variant c.769_770del (p.E257Kfs*15) at a heterozygous state were reprogrammed by Sendai virus-mediated expression of OCT-4, SOX2, c-Myc and KLF4 to hiPSCs.