Britya Ghosh

Hepatic Cell News

MiR-129-5p Exerts Wnt Signaling-Dependent Tumor-Suppressive Functions in Hepatocellular Carcinoma by Directly Targeting Hepatoma-Derived Growth Factor HDGF

[Cancer Cell International] Scientists characterized the epigenetically regulated miR-129-5p regarding its functional effects and target genes to understand its relevance for hepatocellular carcinoma tumorigenesis.

Hepatic Cell News

A New Liver-Regeneration Molecular Mechanism Involving Hepatic Stellate Cells, Kupffer Cells, and Glucose-Regulated Protein 78 as a New Hepatotrophic Factor

[Journal of Hepato-Biliary-Pancreatic Sciences] The authors focused on liver-regeneration mechanisms by the activation of hepatic stellate cells (HSC) and Kupffer cells (KC). It is known that the HSC-secreted Mac-2-binding protein glycan isomer (M2BPGi) activates KC in the fibrotic liver.

Hepatic Cell News

METTL3-Mediated Macrophage Exosomal NEAT1 Contributes to Hepatic Fibrosis Progression through Sp1/TGF-β1/Smad Signaling Pathway

[Cell Death Discovery] Scientists identified the roles of exosomal NEAT1 derived from macrophages on hepatic fibrosis and the underlying mechanisms.

Hepatic Cell News

Nanocurcumin and Curcumin Prevent N, N’-Methylenebisacrylamide-Induced Liver Damage and Promotion of Hepatic Cancer Cell Growth

[Scientific Reports] Curcumin and nanocurcumin reduced HepG2 and Huh-7 cancer cell viability and increased apoptosis in the presence and absence of Acrylamide (AC), while AC alone promoted proliferation.

Hepatic Cell News

Prohaptoglobin Inhibits the Transforming Growth Factor-β-Induced Epithelial-to-Mesenchymal Transition In Vitro by Increasing Smad1/5 Activation and Suppressing the Smad2/3 Signaling Pathway in SK-Hep1 Liver Cancer...

[PLoS One] Researchers demonstrated that prohaptoglobin stimulated Smad1/5 activation via ALK1, a transforming growth factor-β (TGF-β) type I receptor, in endothelial cells, suggesting that proHp played a role in TGF-β signaling.

Hepatic Cell News

Protective Effects of Epigallocatechin-3-O-Gallate Combined with Organic Selenium against Transforming Growth Factor-Beta 1-Induced Fibrosis in LX-2 Cells

[Journal of Food Biochemistry] Researchers investigated the protective effects and possible mechanism of epigallocatechin-3-o-gallate combined with organic selenium in transforming growth factor (TGF)-β1-activated LX-2 cells.

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circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

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Britya Ghosh

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