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Danielle Corrigan

2D Materials and Primary Human Dendritic Cells: A Comparative Cytotoxicity Study

[Small] By using primary human DCs, scientists showed that hexagonal boron nitride, graphene oxide and molybdenum disulphide had minimal effects on the viability of primary human dendritic cells.

Inflammation and Atherosclerosis: Signaling Pathways and Therapeutic Intervention

[Signal Transduction and Targeted Therapy] Scientists summarize the knowledge on cellular participants and key inflammatory signaling pathways in atherosclerosis, and discuss the preclinical studies targeting these key pathways for atherosclerosis, the clinical trials that are going to target some of these processes, and the effects of quelling inflammation and atherosclerosis in the clinic.

Association of Short-Term Air Pollution Exposure with SARS-CoV-2 Infection among Young Adults in Sweden

[JAMA Network Open] The authors suggested that short-term exposure to particulate matter and black carbon was associated with increased risk of positive polymerase chain reaction test results for SARS-CoV-2

An Adjuvanted Zoster Vaccine Elicits Potent Cellular Immune Responses in Mice without QS21

[NPJ Vaccines] Investigators evaluated the immunogenicity of a newly formulated gE protein-based herpes zoster vaccine containing Second-generation Lipid Adjuvant, a synthetic TLR4 ligand, formulated in an oil-in-water emulsion without QS21/

Heterologous Prime-Boost Vaccination Based on Polymorphic Protein D Protects against Intravaginal Chlamydia trachomatis Infection in Mice

[Scientific Reports] Researchers designed a Chlamydia trachomatis vaccine based on a fragment of polymorphic protein D that proved to be immunogenic enough to generate a robust systemic and mucosal IgG humoral immune response in two strains of mice.

Extracellular Nucleoprotein Exacerbates Influenza Virus Pathogenesis by Activating Toll-Like Receptor 4 and the NLRP3 Inflammasome

[Cellular & Molecular Immunology] Scientists showed that internal influenza virus proteins were released from infected cells. Among these proteins, nucleoprotein played a critical role in viral pathogenesis by stimulating neighboring cells through toll-like receptor (TLR) 2, TLR4, and the NLR family pyrin domain containing 3 (NLRP3) inflammasome.

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Merck Announces Phase III KEYNOTE-811 Trial Met Dual Primary Endpoint of Overall Survival as First-Line Treatment in Patients with HER2-Positive Advanced Gastric or Gastroesophageal...

[Merck & Co., Inc.] Merck announced that the Phase 3 KEYNOTE-811 trial evaluating KEYTRUDA®, in combination with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy met its dual primary endpoint of overall survival for the first-line treatment of patients with HER2-positive locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.

Androgen Receptor Splice Variants Drive Castration-Resistant Prostate Cancer Metastasis by Activating Distinct Transcriptional Programs

[Journal Of Clinical Investigation] Investigators found that, under castrated conditions, androgen receptor (AR)-V7 strongly induced osteoblastic bone lesions, a response not observed with full-length AR overexpression.

Prostate Cancer Screening Methods Trialed in ‘Pivotal Moment’

[The Guardian] Methods of screening men for prostate cancer will be trialed in an attempt to save thousands of lives in the UK each year, in what has been hailed as a “pivotal moment” by experts.