Danielle Corrigan

Immunology of Infectious Disease News

Smallpox Vaccination Induces a Substantial Increase in Commensal Skin Bacteria That Promote Pathology and Influence the Host Response

[PLoS Pathogens] The authors reported that intradermal vaccination with vaccinia virus induced a large increase in the number of commensal bacteria in infected tissue, which enhanced recruitment of inflammatory cells, promoted tissue damage, and influenced the host response.

Immunology of Infectious Disease News

Cocrystal Pharma Collaborates with the National Institute of Allergy and Infectious Diseases to Evaluate COVID-19 Protease Inhibitors

[Cocrystal Pharma, Inc.] Cocrystal Pharma, Inc. announced a non-clinical evaluation agreement with the National Institute of Allergy and Infectious Diseases for exploratory preclinical studies to evaluate the potential of Cocrystal’s 3CL protease inhibitors for the treatment of COVID-19.

Immunology of Infectious Disease News

NRx Pharmaceuticals Files New Breakthrough Therapy Designation Request for ZYESAMI® (Aviptadil) in Subgroup of Patients with Critical COVID-19 with Respiratory Failure That Were Also...

[NRx Pharmaceuticals, Inc.] NRx Pharmaceuticals, Inc. announced that it has filed a new breakthrough therapy designation request with the US FDA focused on a subgroup of patients with Critical COVID-19 that in addition to aviptadil or placebo were also treated with remdesivir.

Immunology of Infectious Disease News

FDA Approves Direct Biologics to Proceed with a Landmark Phase III Acute Respiratory Distress Syndrome (ARDS) Trial

[Direct Biologics] Direct Biologics announced that the FDA has approved the company to proceed with its Phase III clinical trial using its investigational EV drug, ExoFlo, to treat ARDS due to COVID-19.

Extracellular Matrix News

HDAC6 Regulates NF-κB Signaling to Control Chondrocyte IL-1-Induced MMP and Inflammatory Gene Expression

[Scientific Reports] HDAC6 was required for both the interleukin (IL)-1 induction of MMP expression and pro-inflammatory interleukin expression in chondrocytes, implicating an effect on NF-κB signaling.

Extracellular Matrix News

Programming Cellular Alignment in Engineered Cardiac Tissue via Bioprinting Anisotropic Organ Building Blocks

[Advanced Materials] The authors reported the fabrication of aligned cardiac tissues via bioprinting anisotropic organ building blocks composed of human induced pluripotent stem cell-derived cardiomyocytes.

1...312313314 Page 313 of 314

Merck Announces Phase III KEYNOTE-811 Trial Met Dual Primary Endpoint of Overall Survival as First-Line Treatment in Patients with HER2-Positive Advanced Gastric or Gastroesophageal...

[Merck & Co., Inc.] Merck announced that the Phase 3 KEYNOTE-811 trial evaluating KEYTRUDA®, in combination with trastuzumab and fluoropyrimidine- and platinum-containing chemotherapy met its dual primary endpoint of overall survival for the first-line treatment of patients with HER2-positive locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma.

Androgen Receptor Splice Variants Drive Castration-Resistant Prostate Cancer Metastasis by Activating Distinct Transcriptional Programs

[Journal Of Clinical Investigation] Investigators found that, under castrated conditions, androgen receptor (AR)-V7 strongly induced osteoblastic bone lesions, a response not observed with full-length AR overexpression.

Prostate Cancer Screening Methods Trialed in ‘Pivotal Moment’

[The Guardian] Methods of screening men for prostate cancer will be trialed in an attempt to save thousands of lives in the UK each year, in what has been hailed as a “pivotal moment” by experts.

All Articles by Author:

Danielle Corrigan

Popular