Danielle Corrigan

Intestinal Cell News

Hsa_circ_0000437 Promotes Pathogenesis of Gastric Cancer and Lymph Node Metastasis

[Oncogene] The authors revealed significant differences in coronin-like actin-binding protein 1C derived circRNA hsa_circ_0000437 between gastric cancer and para-cancer tissues.

Intestinal Cell News

PLGA-Microspheres-Carried circGMCL1 Protects Against Crohn’s Colitis Through Alleviating NLRP3 Inflammasome-Induced Pyroptosis by Promoting Autophagy

[Cell Death & Disease] CircRNA microarray and quantitative real time-polymerase chain reaction analyses were performed to investigate and verify the candidate dysregulated circRNA.

Intestinal Cell News

Circular RNA circPGD Contributes to Gastric Cancer Progression via the Sponging miR-16-5p/ABL2 Axis and Encodes a Novel Pgd-219aa Protein

[Cell Death Discovery] Functionally, circPGD promoted cell proliferation, migration, and suppressed apoptosis in vitro. Mechanistically, circPGD sponged miR-16-5p for relieving miR-16-5p suppression on the corresponding target ABL2 via the SMAD2/3 and YAP signaling pathways.

Intestinal Cell News

The Role of Goblet Cells and Mucus in Intestinal Homeostasis

[Nature Reviews Gastroenterology & Hepatology] The authors present an overview of the current understanding of the role of goblet cells and the mucus layer in maintaining intestinal health during steady-state and how alterations to these systems contribute to inflammatory and infectious disease.

Mammary Cell News

ZNF276 Promotes the Malignant Phenotype of Breast Carcinoma by Activating the CYP1B1-Mediated Wnt/β-Catenin Pathway

[Cell Death & Disease] RNA-sequencing and CUT&Tag assay revealed that ZNF276 controlled a variety of growth and metastasis-related genes expression.

Mammary Cell News

Connexins Orchestrate Progression of Breast Cancer Metastasis to the Brain by Promoting FAK Activation

[Science Translational Medicine] Researchers described a preclinical model of breast cancer metastasis to the brain in mice, and uncovered molecular mechanisms involed in metastatic dissemination and colonization of the brain.

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Generation of Allogeneic CAR-NKT Cells from Hematopoietic Stem and Progenitor Cells Using a Clinically Guided Culture Method

[Nature Biotechnology] The authors described a clinically guided method to differentiate and expand IL-15-enhanced allogeneic CAR-NKT cells with high yield and purity.

Efficacy and Safety of Novel Multifunctional M10 CAR-T Cells in HIV-1-Infected Patients: A Phase I, Multicenter, Single-Arm, Open-Label Study

[Cell Discovery] Investigators reported newly developed anti-HIV-1 CAR-T cells armed with endogenic broadly neutralizing antibodies (bNAbs) and the follicle-homing receptor CXCR5, termed M10 cells.

CD271 mRNA/hnRNPA2B1 Complex Promotes Proliferation and Stemness in Oral and Head and Neck Squamous Cell Carcinoma

[Cancer Science] The authors show edthat CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. They established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines.

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Danielle Corrigan

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