Danielle Corrigan

[Toxicology Mechanisms and Methods] Using sulfur mustard analog 2-chloroethyl ethyl sulfide, researchers established an in vitro model by poisoning cultured immortalized human bronchial epithelial cells.

[Immunological investigations] The effects of neutrophil elastase (ELANE)-mediated M2 macrophages on lung cancer cell proliferation, migration, and invasion and tumor growth were investigated by in vitro and in vivo experiments after co-culture of macrophage conditioned medium and lung cancer cell lines A549 and H1299.

[Biochimica et Biophysica Acta-Reviews On Cancer] To outline the road of SCLC towards precision oncology, the authors summarize the progresses and achievements made in precision treatment in SCLC in genomic, transcriptomic, epigenetic, proteomic, and metabolic dimensions.

[aTyr Pharma, Inc.] aTyr Pharma, Inc. announced that the US FDA has granted the company Fast Track designation for its lead therapeutic candidate, efzofitimod, for the treatment of SSc-Ild.

[Eloxx Pharmaceuticals, Inc.] Eloxx Pharmaceuticals, Inc. announced topline results from the Phase II clinical trial of ELX-02 in combination with ivacaftor in Class 1 CF patients with at least one nonsense mutation.

[Science Signaling] Investigators identified a second adhesion complex localized at the proximal base region of microvilli. This complex contained the immunoglobulin superfamily member TMIGD1, which directly interacted with the microvillar scaffolding proteins EBP50 and E3KARP.