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Ishira
Mesenchymal Cell News
Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes for Treating Traumatic Pancreatitis in Rats
[Stem Cell Research & Therapy] Scientists established a rat model of traumatic pancreatitis and evaluated and compared the therapeutic effects of human umbilical cord (hUC)-MSCs and hucMSC-exosomes.
Mesenchymal Cell News
Standard Toxicity Study of Clinical-Grade Allogeneic Human Bone Marrow-Derived Clonal Mesenchymal Stromal Cells
[Stem Cell Research & Therapy] Investigators determined the probable toxicity effects of local and systemic injections of cryopreserved human bone marrow-derived clonal MSCs during subacute and subchronic periods of time.
Mesenchymal Cell News
Magnetic Exposure Using Samarium Cobalt (SmCO5) Increased Proliferation and Stemness of Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs)
[Scientific Reports] Researchers investigated the impact of induced static MF on hUC-MSCs using SmCO5.
Cancer Stem Cell News
Knockdown of the Stem Cell Marker Musashi-1 Inhibits Endometrial Cancer Growth and Sensitizes Cells to Radiation
[Stem Cell Research & Therapy] Musashi-1 knockdown resulted in a strong decrease in endometrial cancer proliferation and a loss of radioresistance, suggesting therapeutic potential.
Newsletters
Suppression of Nuclear GSK3 Signaling Promotes Serine/One-Carbon Metabolism and Confers Metabolic Vulnerability in Lung Cancer Cells
[Science Advances] Scientists uncovered a critical role of glycogen synthase kinase 3 (GSK3) in regulating the expression of serine/one-carbon metabolic enzymes.
Newsletters
MERS-CoV Endoribonuclease and Accessory Proteins Jointly Evade Host Innate Immunity during Infection of Lung and Nasal Epithelial Cells
[Proceedings of the National Academy of Sciences of the United States of America] Researchers investigated the antagonist effects of the conserved coronavirus endoribonuclease, in combination with NS4a or NS4b.
Popular
Targeting EMT Using Low-Dose Teniposide by Downregulating ZEB2-Driven Activation of RNA Polymerase I in Breast Cancer
[Cell Death & Disease] Researchers demonstrated Teniposide as a potent modulator of the epithelial–mesenchymal transition (EMT) program, specifically through an interferon regulatory factor 7 (IRF7)–N-myc and STAT interactor (NMI) mediated response.
A Prismatic View of the Epigenetic-Metabolic Regulatory Axis in Breast Cancer Therapy Resistance
[Oncogene] The authors discuss interconnected epigenetic and metabolic regulatory pathways and then integrate them into an observable cancer metabolism-therapy-resistance axis that may inform clinical intervention.
SUCNR1 Regulates Insulin Secretion and Glucose Elevates the Succinate Response in People with Prediabetes
[Journal Of Clinical Investigation] Scientists reported that the succinate receptor (SUCNR1) was expressed in β-cells and was up-regulated in hyperglycemic states in mice and humans.
