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Ishira

Molecular Subtyping of Small Cell Lung Cancer

[Seminars in Cancer Biology] The authors summarize the evolution of mutation-based molecular subtyping of SCLC, as well as the trends in molecular targeting and immunotherapeutic for SCLC.

Cancer-Associated Fibroblasts in Non-small Cell Lung Cancer: From Molecular Mechanisms to Clinical Implications

[International Journal of Cancer] Scientists summarize the tumor-promoting role and molecular mechanisms of cancer-associated fibroblasts in NSCLC, including their origin, phenotypic changes and heterogeneity, and their functional roles in carcinogenesis.

Prognostic Value of Myosteatosis in Patients with Lung Cancer: A Systematic Review and Meta-Analysis

[International Journal of Clinical Oncology] Myosteatosis might serve as an independent indicator of unfavorable survival outcomes for overall survival and progression-free survival in lung cancer patients.

Avalo Therapeutics Announces First Patient Dosed in the Phase II PEAK Trial of AVTX-002 for the Treatment of Non-Eosinophilic Asthma (NEA)

[Avalo Therapeutics, Inc.] Avalo Therapeutics, Inc. announced that the first patient has been dosed in the company’s Phase II PEAK trial evaluating AVTX-002 for the treatment of NEA.

Successful Completion of Phase I Study for Lead Asset EP395

[EpiEndo Pharmaceuticals (B3CNewswire, Inc.)] EpiEndo Pharmaceuticals, the clinical-stage biopharmaceutical company developing disease-modifying therapeutics for chronic respiratory disorders, has completed its Phase I First Time in Human study with EP395 in healthy subjects.

CUB Domain Containing Protein 1 (CDCP1) Is a Target for Radioligand Therapy in Castration Resistant Prostate Cancer including PSMA Null Disease

[Clinical Cancer Research] Researchers evaluated if the cell surface protein CDCP1 could be exploited to treat metastatic CRPC with radioligand therapy, including in PSMA low subsets.

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CAR Affinity Modulates the Sensitivity of CAR-T Cells to PD-1/PD-L1-Mediated Inhibition

[Nature Communications] The authors interrogated CAR-T cells targeting HER2 with either low or high affinity in various preclinical models.

Emx2 Underlies the Development and Evolution of Marsupial Gliding Membranes

[Nature] By combining epigenomics, transcriptomics and in-pouch marsupial transgenics, scientists showed that Emx2 was a critical upstream regulator of patagium development.

Designing Biomimetic 3D-Printed Osteochondral Scaffolds for Enhanced Load-Bearing Capacity

[Tissue Engineering Part A] Cmputational simulations revealed that interfacial fibrils within a bilayer alter osteochondral scaffold deformation patterns by redirecting load-induced stresses toward the top of the cartilage layer.